ENSDARG00000012066


Danio rerio

Features
Gene ID: ENSDARG00000012066
  
Biological name :dcn
  
Synonyms : dcn / decorin
  
Possible biological names infered from orthology : P07585 / P28654
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 16368762
Gene end: 16412084
  
Corresponding Affymetrix probe sets: Dr.16078.1.S1_at (Zebrafish Array)   NM_131697_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000025940
Ensembl peptide - ENSDARP00000145539
NCBI entrez gene - 64698     See in Manteia.
RefSeq - NM_131697
RefSeq Peptide - NP_571772
swissprot - Q5RI45
ZFIN ID - ZDB-GENE-010102-1
Ensembl - ENSDARG00000012066
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DCNENSGALG00000011274Gallus gallus
 DCNENSG00000011465Homo sapiens
 DcnENSMUSG00000019929Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bgnb / biglycan b / BGN* / P21810* / P28653* / biglycan*ENSDARG0000000294551
bgna / biglycan a / BGN* / P21810* / P28653* / biglycan*ENSDARG0000001788449
aspn / asporin (LRR class 1) / Q99MQ4* / Q9BXN1* / asporin*ENSDARG0000000219247
prelp / proline/arginine-rich end leucine-rich repeat protein / Q9JK53* / P51888* / proline arginine-rich end leucine-rich repeat* / proline and arginine rich end leucine rich repeat protein*ENSDARG0000007059728
wu:fc23c09ENSDARG0000008800227
lum / lumican / P51884* / P51885*ENSDARG0000004558027
ecm2 / extracellular matrix protein 2, female organ and adipocyte specific / O94769* / Q5FW85* / extracellular matrix protein 2*ENSDARG0000007154926
fmoda / fibromodulin a / FMOD* / P50608* / Q06828* / fibromodulin*ENSDARG0000004489526
si:dkey-6n6.1ENSDARG0000006248726
kera / Q5RI43 / keratocan / O35367* / O60938*ENSDARG0000005693825
zgc:113307ENSDARG0000004489425
fmodb / fibromodulin b / FMOD* / P50608* / Q06828* / fibromodulin*ENSDARG0000001029425
omd / osteomodulin / O35103* / Q99983*ENSDARG0000009360024
si:dkey-32e6.6ENSDARG0000007085723
podn / podocan / Q7TQ62* / Q7Z5L7*ENSDARG0000001902522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR016352  Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
 IPR028549  Decorin
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050654 chondroitin sulfate proteoglycan metabolic process IDA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased length , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased length , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage bent , abnormal
pharyngeal arch cartilage condensed , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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