ENSG00000011465


Homo sapiens

Features
Gene ID: ENSG00000011465
  
Biological name :DCN
  
Synonyms : DCN / decorin / P07585
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q21.33
Gene start: 91140484
Gene end: 91183123
  
Corresponding Affymetrix probe sets: 201893_x_at (Human Genome U133 Plus 2.0 Array)   209335_at (Human Genome U133 Plus 2.0 Array)   211813_x_at (Human Genome U133 Plus 2.0 Array)   211896_s_at (Human Genome U133 Plus 2.0 Array)   239786_at (Human Genome U133 Plus 2.0 Array)   240556_at (Human Genome U133 Plus 2.0 Array)   242605_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449438
Ensembl peptide - ENSP00000449408
Ensembl peptide - ENSP00000449782
Ensembl peptide - ENSP00000052754
Ensembl peptide - ENSP00000376862
Ensembl peptide - ENSP00000398514
Ensembl peptide - ENSP00000399815
Ensembl peptide - ENSP00000401021
Ensembl peptide - ENSP00000413723
Ensembl peptide - ENSP00000446527
Ensembl peptide - ENSP00000446530
Ensembl peptide - ENSP00000447654
Ensembl peptide - ENSP00000447674
Ensembl peptide - ENSP00000447886
Ensembl peptide - ENSP00000448057
Ensembl peptide - ENSP00000448274
Ensembl peptide - ENSP00000448853
Ensembl peptide - ENSP00000448857
Ensembl peptide - ENSP00000449014
NCBI entrez gene - 1634     See in Manteia.
OMIM - 125255
RefSeq - NM_133506
RefSeq - NM_001920
RefSeq - NM_133503
RefSeq - NM_133504
RefSeq - NM_133505
RefSeq - NM_133507
RefSeq - XM_005268693
RefSeq - XM_006719270
RefSeq - XM_017018917
RefSeq Peptide - NP_598014
RefSeq Peptide - NP_001911
RefSeq Peptide - NP_598010
RefSeq Peptide - NP_598011
RefSeq Peptide - NP_598012
RefSeq Peptide - NP_598013
swissprot - F8VNW0
swissprot - F8VSI3
swissprot - F8VU58
swissprot - F8VUF6
swissprot - F8VWU0
swissprot - F8VX58
swissprot - H0YI87
swissprot - F8VXZ8
swissprot - H0YIH3
swissprot - P07585
swissprot - A0A024RBG6
swissprot - Q6FH10
swissprot - F8VNV6
Ensembl - ENSG00000011465
  
Related genetic diseases (OMIM): 610048 - Corneal dystrophy, congenital stromal, 610048
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcnENSDARG00000012066Danio rerio
 DCNENSGALG00000011274Gallus gallus
 DcnENSMUSG00000019929Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BGN / P21810 / biglycanENSG0000018249256
ASPN / Q9BXN1 / asporinENSG0000010681952
LUM / P51884 / lumicanENSG0000013932929
PRELP / P51888 / proline and arginine rich end leucine rich repeat proteinENSG0000018878328
ECM2 / O94769 / extracellular matrix protein 2ENSG0000010682326
PODN / Q7Z5L7 / podocanENSG0000017434825
FMOD / Q06828 / fibromodulinENSG0000012217625
OMD / Q99983 / osteomodulinENSG0000012708325
KERA / O60938 / keratocanENSG0000013933024
PODNL1 / Q6PEZ8 / podocan like 1ENSG0000013200024


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR016352  Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
 IPR028549  Decorin
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010508 positive regulation of autophagy IDA
 biological_processGO:0010596 negative regulation of endothelial cell migration IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0016239 positive regulation of macroautophagy IGI
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0030206 chondroitin sulfate biosynthetic process TAS
 biological_processGO:0030207 chondroitin sulfate catabolic process TAS
 biological_processGO:0030208 dermatan sulfate biosynthetic process TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IGI
 biological_processGO:0090141 positive regulation of mitochondrial fission IGI
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005589 collagen type VI trimer IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0043202 lysosomal lumen TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000486 Strabismus "Strabismus (also known as squint) is a condition in which the eyes are not properly aligned with each other." [HPO:curators]
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 HP:0000501 Glaucoma "Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure." [HPO:curators]
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 HP:0000529 Progressive visual loss 
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 HP:0008005 Congenital corneal dystrophy 
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 HP:0011487 Increased corneal thickness "A increased anteroposterior thickness of the cornea." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087245 MMP2 / P08253 / matrix metallopeptidase 2  / reaction
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / reaction / complex
 ENSG00000119699 TGFB3 / P10600 / transforming growth factor beta 3  / reaction / complex
 ENSG00000137673 MMP7 / P09237 / matrix metallopeptidase 7  / reaction
 ENSG00000157227 MMP14 / P50281 / matrix metallopeptidase 14  / reaction
 ENSG00000149968 MMP3 / P08254 / matrix metallopeptidase 3  / reaction
 ENSG00000187045 Q8IU80 / TMPRSS6 / transmembrane serine protease 6  / reaction
 ENSG00000092969 TGFB2 / P61812 / transforming growth factor beta 2  / complex / reaction






 

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