ENSMUSG00000016942


Mus musculus

Features
Gene ID: ENSMUSG00000016942
  
Biological name :Tmprss6
  
Synonyms : Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q9DBI0 / Tmprss6
  
Possible biological names infered from orthology : Q8IU80 / transmembrane serine protease 6
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 78439667
Gene end: 78468634
  
Corresponding Affymetrix probe sets: 10430324 (MoGene1.0st)   1428676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155401
Ensembl peptide - ENSMUSP00000017086
Ensembl peptide - ENSMUSP00000155355
Ensembl peptide - ENSMUSP00000155549
Ensembl peptide - ENSMUSP00000155414
Ensembl peptide - ENSMUSP00000155435
NCBI entrez gene - 71753     See in Manteia.
MGI - MGI:1919003
RefSeq - XM_006521417
RefSeq - XM_006521416
RefSeq - NM_027902
RefSeq - NM_001355601
RefSeq Peptide - NP_082178
RefSeq Peptide - NP_001342530
swissprot - Q9DBI0
Ensembl - ENSMUSG00000016942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TMPRSS6ENSGALG00000012483Gallus gallus
 Q8IU80ENSG00000187045Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
St14 / P56677 / suppression of tumorigenicity 14 (colon carcinoma) / Q9Y5Y6* / suppression of tumorigenicity 14*ENSMUSG0000003199531
Q8BIK6 / Tmprss7 / Transmembrane protease serine 7 / Q7RTY8* / transmembrane serine protease 7*ENSMUSG0000003317726
Corin / Q9Z319 / Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic peptide-converting enzyme, activated prot...ENSMUSG0000000522023
P97435 / Tmprss15 / transmembrane protease, serine 15 / P98073* / transmembrane serine protease 15*ENSMUSG0000002285720
Tmprss9 / transmembrane protease, serine 9 / Q7Z410* / transmembrane serine protease 9*ENSMUSG0000005940619
Tmprss13 / transmembrane serine protease 13 / Q9BYE2*ENSMUSG0000003712917
Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*ENSMUSG0000010976417
Q8K1T0 / Tmprss3 / transmembrane protease, serine 3 / P57727* / transmembrane serine protease 3*ENSMUSG0000002403417
F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*ENSMUSG0000003164517
Q9JIQ8 / Tmprss2 / Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain / O15393* / transmembrane serine protease 2*ENSMUSG0000000038516
Q9ER04 / Tmprss5 / transmembrane protease, serine 5 (spinesin) / Q9H3S3* / transmembrane serine protease 5*ENSMUSG0000003226816
Q8VCA5 / Tmprss4 / Transmembrane protease serine 4 / Q9NRS4* / transmembrane serine protease 4*ENSMUSG0000003209115
Hpn / O35453 / Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain / hepsin* / P05981*ENSMUSG0000000124914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000082  SEA domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009003  Peptidase S1, PA clan
 IPR017118  Peptidase S1A, matriptase-2
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036055  LDL receptor-like superfamily
 IPR036364  SEA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IGI
 biological_processGO:0033619 membrane protein proteolysis IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0097264 self proteolysis IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tmprss6m2Btlr/Tmprss6m2Btlr
Genetic Background: C57BL/6J-Tmprss6m2Btlr

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Tmprss6hem8/Tmprss6hem8
Genetic Background: C57BL/6J-Tmprss6hem8

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Themism2Btlr/Themism2Btlr
Genetic Background: C57BL/6J-Themism2Btlr

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0001670 abnormal mineral absorption "anomalous ability of the body to take in any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dicer1tm1Snj/Dicer1tm1Snj,Tg(KRT5-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002224 abnormal spleen size "deviation from the normal spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Tmprss6hem8/Tmprss6hem8
Genetic Background: C57BL/6J-Tmprss6hem8

Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003582 abnormal ovary development "abnormal morphogenesis of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tmprss6m2Btlr/Tmprss6m2Btlr
Genetic Background: C57BL/6J-Tmprss6m2Btlr

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6hem8/Tmprss6hem8
Genetic Background: C57BL/6J-Tmprss6hem8

Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6hem8/Tmprss6hem8
Genetic Background: C57BL/6J-Tmprss6hem8

Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005563 abnormal hemoglobin content "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6hem8/Tmprss6hem8
Genetic Background: C57BL/6J-Tmprss6hem8

Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008738 abnormal liver iron level "anomaly in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0008739 abnormal spleen iron level "anomaly in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0008743 decreased liver iron level "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Tmprss6hem8/Tmprss6hem8
Genetic Background: C57BL/6J-Tmprss6hem8

Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008801 abnormal erythroid progenitor cell morphology "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6+
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmprss6m2Btlr/Tmprss6m2Btlr
Genetic Background: C57BL/6J-Tmprss6m2Btlr

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010682 abnormal hair follicle infundibulum morphology "any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface" [PMID:19211055]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010689 thin hair follicle outer rooth sheath "reduced thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

 MP:0011284 abnormal circulating erythropoietin level "anomalous blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+,Tmprss6tm1Otin/Tmprss6tm1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0011896 increased circulating unsaturated transferrin level "increase in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: B6.129P2-Tmprss6tm1Dgen/Crl

Allelic Composition: Tmprss6hem8/Tmprss6hem8
Genetic Background: C57BL/6J-Tmprss6hem8

Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0013303 decreased pancreas iron level "reduction in the amount of iron present in the pancreas tissue" [MGI:mlaw]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0020368 decreased heart iron level "reduction in the amount of iron present in the heart tissue" [MGI:Anna]
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Allelic Composition: Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Hfe2tm1Nca/Hfe2+,Tmprss6tm1Dgen/Tmprss6tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / reaction
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / reaction
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / reaction
 ENSMUSG00000019929 Dcn / P28654 / Decorin / P07585*  / reaction






 

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