ENSMUSG00000024034


Mus musculus

Features
Gene ID: ENSMUSG00000024034
  
Biological name :Tmprss3
  
Synonyms : Q8K1T0 / Tmprss3 / transmembrane protease, serine 3
  
Possible biological names infered from orthology : P57727 / transmembrane serine protease 3
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 31179272
Gene end: 31198975
  
Corresponding Affymetrix probe sets: 10449672 (MoGene1.0st)   1421714_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024833
Ensembl peptide - ENSMUSP00000110196
NCBI entrez gene - 140765     See in Manteia.
MGI - MGI:2155445
RefSeq - XM_017317241
RefSeq - NM_001163776
RefSeq - NM_080727
RefSeq Peptide - NP_542765
RefSeq Peptide - NP_001157248
swissprot - Q3TZ06
swissprot - Q8K1T0
Ensembl - ENSMUSG00000024034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-22n8.2ENSDARG00000036545Danio rerio
 tmprss3aENSDARG00000053315Danio rerio
 TMPRSS3ENSGALG00000016169Gallus gallus
 P57727ENSG00000160183Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JIQ8 / Tmprss2 / Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain / O15393* / transmembrane serine protease 2*ENSMUSG0000000038539
Tmprss13 / transmembrane serine protease 13 / Q9BYE2*ENSMUSG0000003712935
Q8VCA5 / Tmprss4 / Transmembrane protease serine 4 / Q9NRS4* / transmembrane serine protease 4*ENSMUSG0000003209131
P97435 / Tmprss15 / transmembrane protease, serine 15 / P98073* / transmembrane serine protease 15*ENSMUSG0000002285730
Q9ER04 / Tmprss5 / transmembrane protease, serine 5 (spinesin) / Q9H3S3* / transmembrane serine protease 5*ENSMUSG0000003226829
Hpn / O35453 / Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain / hepsin* / P05981*ENSMUSG0000000124929
Q9DBI0 / Tmprss6 / Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q8IU80* / transmembrane serine protease 6*ENSMUSG0000001694229
St14 / P56677 / suppression of tumorigenicity 14 (colon carcinoma) / Q9Y5Y6* / suppression of tumorigenicity 14*ENSMUSG0000003199527
F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*ENSMUSG0000003164527
Corin / Q9Z319 / Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic peptide-converting enzyme, activated prot...ENSMUSG0000000522027
Q8BIK6 / Tmprss7 / Transmembrane protease serine 7 / Q7RTY8* / transmembrane serine protease 7*ENSMUSG0000003317727
Tmprss9 / transmembrane protease, serine 9 / Q7Z410* / transmembrane serine protease 9*ENSMUSG0000005940626
Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*ENSMUSG0000010976426


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009003  Peptidase S1, PA clan
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036055  LDL receptor-like superfamily
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004325 absent vestibular hair cells "absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004397 absent cochlear inner hair cells "absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004403 absent cochlear outer hair cells "absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0011060 abnormal kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of auditory receptor cells" [GO:0060091]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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