Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000382	underdeveloped hair follicles	"arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0000443	abnormal snout morphology	"anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000479	abnormal intestinal cell	"anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0000489	abnormal large intestine morphology	"structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0000495	abnormal colon morphology	"malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
MP:0000507	absent digestive secretion	"missing the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0000623	reduced salivation	"decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) Allelic Composition: St14^tm3Bug/St14^tm3Bug Genetic Background: involves: 129S6/SvEvTac Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0000764	abnormal tongue epithelium morphology	"malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Abca3^tm1Holz/Abca3^tm1Holz Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: F2rl1^tm1Cgh/F2rl1^tm1Cgh,Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
MP:0001190	reddish skin	"skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0001196	shiny skin	"skin with a glossy or glistening appearance" [J:56641]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001211	wrinkled skin	"irregular folds and/or indentations on the skin" [J:19212]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0001218	thin epidermis	"reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0001239	abnormal granular layer morphology	"structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0001240	abnormal cornified layer morphology	"structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
MP:0001284	absent vibrissae	"missing whiskers" [J:18378]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0001429	dehydration	"excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001665	chronic diarrhea	"prolonged diarrhea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
MP:0001711	abnormal placenta		Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0001716	abnormal placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001874	acanthosis	"diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0002656	abnormal keratinocyte differentiation	"developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0002731	megacolon	"extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
MP:0002796	impaired skin barrier function	"impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^{Gt(RST485)Byg}/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0003054	spina bifida	"common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0003288	intestinal edema	"an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0003403	absent placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]	Show Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug Genetic Background: involves: 129S6/SvEvTac
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0003743	abnormal facial morphology	"anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0003756	abnormal hard palate	"abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Abca3^tm1Holz/Abca3^tm1Holz Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0003809	abnormal hair shaft morphology	"irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003853	dry skin	"skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0004794	increased anti-nuclear antigen antibody level	"elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0004842	abnormal large intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0004974	decreased regulatory T cell number	"reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0005310	abnormal salivary gland physiology	"anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: St14^tm3Bug/St14^tm3Bug Genetic Background: involves: 129S6/SvEvTac
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0008722	abnormal chemokine secretion	"anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0008879	submandibular gland inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0008880	lacrimal gland inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0008882	abnormal enterocyte physiology	"any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0008883	abnormal enterocyte proliferation	"anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hras^tm1Mok/Hras^tm1Mok,Kras^tm1Mok/Kras^tm1Mok,Nras^tm1Mok/Nras^tm1Mok,Tg(HRAS)7Mok/0 Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
MP:0009541	increased thymocyte apoptosis	"increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0009546	absent gastric milk in neonates	"failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0009595	enlarged corneocyte envelope	"increased size of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0009596	abnormal stratum corneum lipid matrix formation	"altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0009597	impaired stratum corneum desquamation	"dysregulated shedding of the outermost layer of corneocytes, affecting the integrity and thickness of the stratum corneum; may result in xerotic and ichthyotic conditions" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm2Bug Genetic Background: involves: 129P2/OlaHsd Allelic Composition: St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd
MP:0009931	abnormal skin appearance	"skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0009932	skin fibrosis	"invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
MP:0010168	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0010169	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0010234	abnormal vibrissa follicle morphology	"any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0010844	increased effector memory CD4-positive, alpha-beta T cell number	"increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0010850	increased effector memory CD8-positive, alpha-beta T cell number	"increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^Gt(XM184)Byg/St14^Gt(XM184)Byg Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14^tm1Bug Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Spint1^tm1Bug/Spint1^tm1Bug,St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rad9a^{tm1.1(KOMP)Wtsi}/Rad9a^{tm1.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Rad9a^{tm1.1(KOMP)Wtsi}/Bay
MP:0011105	partial embryonic lethality between implantation and placentation	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg},St14^tm1Bug/St14⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0020220	decreased tear production	"decreased production of the amount of fluid produced in the eye" [GOC:NV]	Show Allelic Composition: St14^tm2Bug/St14^tm3Bug,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss
MP:0030570	abnormal piliary canal morphology	"any structural anomaly of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft" [PMID:19211055, UBERON:0035610]	Show Allelic Composition: Becn1^tm1Blev/Becn1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

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