ENSMUSG00000000385


Mus musculus

Features
Gene ID: ENSMUSG00000000385
  
Biological name :Tmprss2
  
Synonyms : Q9JIQ8 / Tmprss2 / Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain
  
Possible biological names infered from orthology : O15393 / transmembrane serine protease 2
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 97564684
Gene end: 97611195
  
Corresponding Affymetrix probe sets: 10441254 (MoGene1.0st)   1419154_at (Mouse Genome 430 2.0 Array)   1449369_at (Mouse Genome 430 2.0 Array)   1458347_s_at (Mouse Genome 430 2.0 Array)   1459510_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000395
NCBI entrez gene - 50528     See in Manteia.
MGI - MGI:1354381
RefSeq - XM_006523065
RefSeq - NM_015775
RefSeq - XM_006523064
RefSeq Peptide - NP_056590
swissprot - Q9JIQ8
Ensembl - ENSMUSG00000000385
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmprss2ENSDARG00000098686Danio rerio
 TMPRSS2ENSGALG00000016144Gallus gallus
 O15393ENSG00000184012Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K1T0 / Tmprss3 / transmembrane protease, serine 3 / P57727* / transmembrane serine protease 3*ENSMUSG0000002403438
Tmprss13 / transmembrane serine protease 13 / Q9BYE2*ENSMUSG0000003712933
P97435 / Tmprss15 / transmembrane protease, serine 15 / P98073* / transmembrane serine protease 15*ENSMUSG0000002285730
Q8VCA5 / Tmprss4 / Transmembrane protease serine 4 / Q9NRS4* / transmembrane serine protease 4*ENSMUSG0000003209130
Corin / Q9Z319 / Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic peptide-converting enzyme, activated prot...ENSMUSG0000000522029
Q9ER04 / Tmprss5 / transmembrane protease, serine 5 (spinesin) / Q9H3S3* / transmembrane serine protease 5*ENSMUSG0000003226829
Q8BIK6 / Tmprss7 / Transmembrane protease serine 7 / Q7RTY8* / transmembrane serine protease 7*ENSMUSG0000003317728
St14 / P56677 / suppression of tumorigenicity 14 (colon carcinoma) / Q9Y5Y6* / suppression of tumorigenicity 14*ENSMUSG0000003199528
F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*ENSMUSG0000003164527
Hpn / O35453 / Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain / hepsin* / P05981*ENSMUSG0000000124927
Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*ENSMUSG0000010976427
Q9DBI0 / Tmprss6 / Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q8IU80* / transmembrane serine protease 6*ENSMUSG0000001694227
Tmprss9 / transmembrane protease, serine 9 / Q7Z410* / transmembrane serine protease 9*ENSMUSG0000005940625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009003  Peptidase S1, PA clan
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036055  LDL receptor-like superfamily
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0046598 positive regulation of viral entry into host cell IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dcxtm1Caw/Dcx+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003608 prostate inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the prostate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1.1Hwu/Pten+,Tmprss2tm1.1(ERG)Sho/Tmprss2tm1.1(ERG)Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mgat4atm1.1Jxm/Mgat4atm1.1Jxm,Mgat4btm1.1Jxm/Mgat4btm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptentm1.1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ergtm1.1Sho/Ergtm1.1Sho,Ptentm1Hwu/Ptentm1Hwu,Tmprss2tm3Sho/Tmprss2tm3Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009737 prostate gland cysts "benign epithelial growths, often fluid-filled, within the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011385 abnormal testosterone level "anomaly in the concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ptentm1.1Hwu/Pten+,Tmprss2tm1.1(ERG)Sho/Tmprss2tm1.1(ERG)Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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