ENSG00000184012


Homo sapiens

Features
Gene ID: ENSG00000184012
  
Biological name :TMPRSS2
  
Synonyms : O15393 / TMPRSS2 / transmembrane serine protease 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 41464551
Gene end: 41531116
  
Corresponding Affymetrix probe sets: 1570433_at (Human Genome U133 Plus 2.0 Array)   205102_at (Human Genome U133 Plus 2.0 Array)   211689_s_at (Human Genome U133 Plus 2.0 Array)   226553_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391784
Ensembl peptide - ENSP00000381588
Ensembl peptide - ENSP00000397846
Ensembl peptide - ENSP00000389006
Ensembl peptide - ENSP00000391216
Ensembl peptide - ENSP00000330330
NCBI entrez gene - 7113     See in Manteia.
OMIM - 602060
RefSeq - XM_011529731
RefSeq - XM_005261043
RefSeq - XM_011529732
RefSeq - NM_001135099
RefSeq - NM_005656
RefSeq - XM_011529733
RefSeq Peptide - NP_005647
RefSeq Peptide - NP_001128571
swissprot - O15393
swissprot - C9JKZ3
swissprot - C9J5Y1
swissprot - C9JB05
Ensembl - ENSG00000184012
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmprss2ENSDARG00000098686Danio rerio
 TMPRSS2ENSGALG00000016144Gallus gallus
 Q9JIQ8ENSMUSG00000000385Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P57727 / TMPRSS3 / transmembrane serine protease 3ENSG0000016018336
Q9BYE2 / TMPRSS13 / transmembrane serine protease 13ENSG0000013774730
Q9NRS4 / TMPRSS4 / transmembrane serine protease 4ENSG0000013764829
CORIN / Q9Y5Q5 / corin, serine peptidaseENSG0000014524427
Q9H3S3 / TMPRSS5 / transmembrane serine protease 5ENSG0000016668227
P98073 / TMPRSS15 / transmembrane serine protease 15ENSG0000015464626
ST14 / Q9Y5Y6 / suppression of tumorigenicity 14ENSG0000014941826
F11 / P03951 / coagulation factor XIENSG0000008892625
KLKB1 / P03952 / kallikrein B1ENSG0000016434424
HPN / hepsin / P05981ENSG0000010570724
Q7RTY8 / TMPRSS7 / transmembrane serine protease 7ENSG0000017604023
Q8IU80 / TMPRSS6 / transmembrane serine protease 6ENSG0000018704523
Q7Z410 / TMPRSS9 / transmembrane serine protease 9ENSG0000017829722


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009003  Peptidase S1, PA clan
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036055  LDL receptor-like superfamily
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0016540 protein autoprocessing IMP
 biological_processGO:0046598 positive regulation of viral entry into host cell IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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