ENSG00000160183


Homo sapiens

Features
Gene ID: ENSG00000160183
  
Biological name :TMPRSS3
  
Synonyms : P57727 / TMPRSS3 / transmembrane serine protease 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 42371837
Gene end: 42396846
  
Corresponding Affymetrix probe sets: 220177_s_at (Human Genome U133 Plus 2.0 Array)   223948_s_at (Human Genome U133 Plus 2.0 Array)   223949_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000291532
Ensembl peptide - ENSP00000381442
Ensembl peptide - ENSP00000411013
Ensembl peptide - ENSP00000494414
Ensembl peptide - ENSP00000381434
NCBI entrez gene - 64699     See in Manteia.
OMIM - 605511
RefSeq - NM_001256317
RefSeq - NM_024022
RefSeq - NM_032404
RefSeq - NM_032405
RefSeq Peptide - NP_001243246
RefSeq Peptide - NP_076927
RefSeq Peptide - NP_115780
RefSeq Peptide - NP_115781
swissprot - P57727
swissprot - B7WPR2
Ensembl - ENSG00000160183
  
Related genetic diseases (OMIM): 601072 - Deafness, autosomal recessive 8/10, 601072
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-22n8.2ENSDARG00000036545Danio rerio
 tmprss3aENSDARG00000053315Danio rerio
 TMPRSS3ENSGALG00000016169Gallus gallus
 Q8K1T0ENSMUSG00000024034Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15393 / TMPRSS2 / transmembrane serine protease 2ENSG0000018401242
Q9BYE2 / TMPRSS13 / transmembrane serine protease 13ENSG0000013774734
Q9H3S3 / TMPRSS5 / transmembrane serine protease 5ENSG0000016668232
P98073 / TMPRSS15 / transmembrane serine protease 15ENSG0000015464631
Q9NRS4 / TMPRSS4 / transmembrane serine protease 4ENSG0000013764831
HPN / hepsin / P05981ENSG0000010570729
ST14 / Q9Y5Y6 / suppression of tumorigenicity 14ENSG0000014941829
Q8IU80 / TMPRSS6 / transmembrane serine protease 6ENSG0000018704529
CORIN / Q9Y5Q5 / corin, serine peptidaseENSG0000014524429
KLKB1 / P03952 / kallikrein B1ENSG0000016434428
F11 / P03951 / coagulation factor XIENSG0000008892627
Q7RTY8 / TMPRSS7 / transmembrane serine protease 7ENSG0000017604026
Q7Z410 / TMPRSS9 / transmembrane serine protease 9ENSG0000017829725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009003  Peptidase S1, PA clan
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036055  LDL receptor-like superfamily
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis NAS
 biological_processGO:0006883 cellular sodium ion homeostasis IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity NAS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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