ENSG00000149418


Homo sapiens

Features
Gene ID: ENSG00000149418
  
Biological name :ST14
  
Synonyms : Q9Y5Y6 / ST14 / suppression of tumorigenicity 14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q24.3
Gene start: 130159562
Gene end: 130210376
  
Corresponding Affymetrix probe sets: 202005_at (Human Genome U133 Plus 2.0 Array)   216905_s_at (Human Genome U133 Plus 2.0 Array)   216906_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000278742
NCBI entrez gene - 6768     See in Manteia.
OMIM - 606797
RefSeq - NM_021978
RefSeq Peptide - NP_068813
swissprot - Q9Y5Y6
Ensembl - ENSG00000149418
  
Related genetic diseases (OMIM): 602400 - Ichthyosis, congenital, autosomal recessive 11, 602400
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 st14aENSDARG00000061173Danio rerio
 st14bENSDARG00000044655Danio rerio
 ST14ENSGALG00000001331Gallus gallus
 St14ENSMUSG00000031995Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IU80 / TMPRSS6 / transmembrane serine protease 6ENSG0000018704529
Q7RTY8 / TMPRSS7 / transmembrane serine protease 7ENSG0000017604025
CORIN / Q9Y5Q5 / corin, serine peptidaseENSG0000014524422
P98073 / TMPRSS15 / transmembrane serine protease 15ENSG0000015464621
F11 / P03951 / coagulation factor XIENSG0000008892617
Q7Z410 / TMPRSS9 / transmembrane serine protease 9ENSG0000017829717
KLKB1 / P03952 / kallikrein B1ENSG0000016434416
O15393 / TMPRSS2 / transmembrane serine protease 2ENSG0000018401216
P57727 / TMPRSS3 / transmembrane serine protease 3ENSG0000016018315
Q9NRS4 / TMPRSS4 / transmembrane serine protease 4ENSG0000013764815
Q9BYE2 / TMPRSS13 / transmembrane serine protease 13ENSG0000013774715
Q9H3S3 / TMPRSS5 / transmembrane serine protease 5ENSG0000016668214
HPN / hepsin / P05981ENSG0000010570714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000082  SEA domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009003  Peptidase S1, PA clan
 IPR017051  Peptidase S1A, matripase
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036055  LDL receptor-like superfamily
 IPR036364  SEA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0060672 epithelial cell morphogenesis involved in placental branching IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001006 Hypotrichosis "Reduced or lacking hair growth." [HPO:curators]
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 HP:0008064 Ichthyosiform abnormality of the skin 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143631 FLG / P20930 / filaggrin  / reaction
 ENSG00000167754 KLK5 / Q9Y337 / kallikrein related peptidase 5  / reaction






 

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