ENSG00000105707


Homo sapiens

Features
Gene ID: ENSG00000105707
  
Biological name :HPN
  
Synonyms : hepsin / HPN / P05981
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.11
Gene start: 35040506
Gene end: 35066571
  
Corresponding Affymetrix probe sets: 204934_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472310
Ensembl peptide - ENSP00000262626
Ensembl peptide - ENSP00000376060
Ensembl peptide - ENSP00000470327
NCBI entrez gene - 3249     See in Manteia.
OMIM - 142440
RefSeq - XM_017026732
RefSeq - NM_002151
RefSeq - NM_182983
RefSeq - XM_005258838
RefSeq - XM_006723181
RefSeq - XM_017026731
RefSeq Peptide - NP_892028
RefSeq Peptide - NP_002142
swissprot - M0QZ63
swissprot - M0R244
swissprot - P05981
swissprot - A0A140VJK9
Ensembl - ENSG00000105707
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpnENSDARG00000027609Danio rerio
 HpnENSMUSG00000001249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P57727 / TMPRSS3 / transmembrane serine protease 3ENSG0000016018332
P98073 / TMPRSS15 / transmembrane serine protease 15ENSG0000015464631
Q9BYE2 / TMPRSS13 / transmembrane serine protease 13ENSG0000013774731
O15393 / TMPRSS2 / transmembrane serine protease 2ENSG0000018401231
Q9H3S3 / TMPRSS5 / transmembrane serine protease 5ENSG0000016668231
KLKB1 / P03952 / kallikrein B1ENSG0000016434430
Q9NRS4 / TMPRSS4 / transmembrane serine protease 4ENSG0000013764829
ST14 / Q9Y5Y6 / suppression of tumorigenicity 14ENSG0000014941829
Q8IU80 / TMPRSS6 / transmembrane serine protease 6ENSG0000018704529
CORIN / Q9Y5Q5 / corin, serine peptidaseENSG0000014524429
Q7Z410 / TMPRSS9 / transmembrane serine protease 9ENSG0000017829728
Q7RTY8 / TMPRSS7 / transmembrane serine protease 7ENSG0000017604028
F11 / P03951 / coagulation factor XIENSG0000008892628


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR015352  Hepsin, SRCR domain
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010756 positive regulation of plasminogen activation IDA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0034769 basement membrane disassembly IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043923 positive regulation by host of viral transcription IDA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway TAS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IDA
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound ISS
 biological_processGO:0071805 potassium ion transmembrane transport ISS
 biological_processGO:0090103 cochlea morphogenesis ISS
 biological_processGO:0097066 response to thyroid hormone ISS
 biological_processGO:0097195 pilomotor reflex ISS
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IDA
 biological_processGO:2000611 positive regulation of thyroid hormone generation ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0015269 calcium-activated potassium channel activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070008 serine-type exopeptidase activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation
Signaling by MST1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105707 HPN / hepsin / P05981  / complex
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction






 

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