ENSDARG00000027609


Danio rerio

Features
Gene ID: ENSDARG00000027609
  
Biological name :hpn
  
Synonyms : hepsin / hpn
  
Possible biological names infered from orthology : O35453 / P05981 / Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 45249055
Gene end: 45288599
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000044096
NCBI entrez gene - 569259     See in Manteia.
RefSeq - NM_001098187
RefSeq - XM_021466731
RefSeq Peptide - NP_001091657
swissprot - A8DZG9
ZFIN ID - ZDB-GENE-141212-373
Ensembl - ENSDARG00000027609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HPNENSG00000105707Homo sapiens
 HpnENSMUSG00000001249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tmprss5 / transmembrane protease, serine 5 / Q9H3S3* / Q9ER04* / transmembrane serine protease 5* / transmembrane protease, serine 5 (spinesin)*ENSDARG0000008771730
tmprss2 / transmembrane protease, serine 2 / O15393* / transmembrane serine protease 2*ENSDARG0000009868630
tmprss4a / transmembrane protease, serine 4a / Q9NRS4* / Q8VCA5* / TMPRSS4* / transmembrane serine protease 4* / Transmembrane protease serine 4 *ENSDARG0000010311730
tmprss4b / transmembrane protease, serine 4b / Q9NRS4* / Q8VCA5* / TMPRSS4* / transmembrane serine protease 4* / Transmembrane protease serine 4 *ENSDARG0000001286030
tmprss3a / transmembrane protease, serine 3a / Q8K1T0* / P57727* / TMPRSS3* / transmembrane serine protease 3* / transmembrane protease, serine 3*ENSDARG0000005331529
st14a / suppression of tumorigenicity 14 (colon carcinoma) a / ST14* / Q9Y5Y6* / P56677* / suppression of tumorigenicity 14* / suppression of tumorigenicity 14 (colon carcinoma)*ENSDARG0000006117329
tmprss13a / transmembrane protease, serine 13a / Q9BYE2* / TMPRSS13* / transmembrane serine protease 13*ENSDARG0000010096928
tmprss13b / transmembrane protease, serine 13b / Q9BYE2* / TMPRSS13* / transmembrane serine protease 13*ENSDARG0000007757328
tmprss9 / transmembrane protease, serine 9 / Q7Z410* / transmembrane serine protease 9*ENSDARG0000002984127
zmp:0000001114ENSDARG0000010008826
CR352265.1ENSDARG0000006275826
tmprss15 / transmembrane protease, serine 15 / P97435* / P98073* / transmembrane serine protease 15*ENSDARG0000007939326
st14b / suppression of tumorigenicity 14 (colon carcinoma) b / ST14* / Q9Y5Y6* / P56677* / suppression of tumorigenicity 14* / suppression of tumorigenicity 14 (colon carcinoma)*ENSDARG0000004465526
corin / corin, serine peptidase / Q9Y5Q5* / Q9Z319* / Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic pep...ENSDARG0000010128125
si:dkey-22n8.2 / Q8K1T0* / P57727* / TMPRSS3* / transmembrane serine protease 3* / transmembrane protease, serine 3*ENSDARG0000003654524
zgc:55888ENSDARG0000001653822
CR352265.4 / Q7RTY8* / TMPRSS7* / transmembrane serine protease 7*ENSDARG0000011657516


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR015352  Hepsin, SRCR domain
 IPR017448  SRCR-like domain
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IMP
 biological_processGO:1900003 regulation of serine-type endopeptidase activity IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070008 serine-type exopeptidase activity IEA


Pathways (from Reactome)
Pathway description
MET Receptor Activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0005654 blood plasma blood plasma decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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