ENSG00000167754


Homo sapiens

Features
Gene ID: ENSG00000167754
  
Biological name :KLK5
  
Synonyms : kallikrein related peptidase 5 / KLK5 / Q9Y337
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.41
Gene start: 50943303
Gene end: 50953093
  
Corresponding Affymetrix probe sets: 222242_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337733
Ensembl peptide - ENSP00000375685
Ensembl peptide - ENSP00000469439
Ensembl peptide - ENSP00000471966
NCBI entrez gene - 25818     See in Manteia.
OMIM - 605643
RefSeq - XM_011526703
RefSeq - NM_001077491
RefSeq - NM_001077492
RefSeq - NM_012427
RefSeq - XM_011526702
RefSeq Peptide - NP_001070960
RefSeq Peptide - NP_036559
RefSeq Peptide - NP_001070959
swissprot - Q9Y337
swissprot - M0QXX2
Ensembl - ENSG00000167754
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000034771Gallus gallus
 Klk5ENSMUSG00000074155Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLK4 / Q9Y5K2 / kallikrein related peptidase 4ENSG0000016774942
KLK7 / P49862 / kallikrein related peptidase 7ENSG0000016903537
KLK12 / Q9UKR0 / kallikrein related peptidase 12ENSG0000018647436
KLK10 / O43240 / kallikrein related peptidase 10ENSG0000012945132


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002803 positive regulation of antibacterial peptide production IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008544 epidermis development TAS
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0097209 epidermal lamellar body IDA
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity TAS
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149418 ST14 / Q9Y5Y6 / suppression of tumorigenicity 14  / reaction
 ENSG00000142615 CELA2A / P08217 / chymotrypsin like elastase family member 2A  / reaction
 ENSG00000133710 Q9NQ38 / SPINK5 / serine peptidase inhibitor, Kazal type 5  / complex / reaction
 ENSG00000129455 KLK8 / O60259 / kallikrein related peptidase 8  / reaction
 ENSG00000143631 FLG / P20930 / filaggrin  / reaction
 ENSG00000178172 Q6UWN8 / SPINK6 / serine peptidase inhibitor, Kazal type 6  / reaction / complex
 ENSG00000204909 Q5DT21 / SPINK9 / serine peptidase inhibitor, Kazal type 9  / complex / reaction






 

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