ENSG00000178172


Homo sapiens

Features
Gene ID: ENSG00000178172
  
Biological name :SPINK6
  
Synonyms : Q6UWN8 / serine peptidase inhibitor, Kazal type 6 / SPINK6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q32
Gene start: 148202794
Gene end: 148215137
  
Corresponding Affymetrix probe sets: 1553973_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324870
Ensembl peptide - ENSP00000481309
Ensembl peptide - ENSP00000421119
NCBI entrez gene - 404203     See in Manteia.
OMIM - 615868
RefSeq - NM_001195290
RefSeq - NM_205841
RefSeq Peptide - NP_001182219
RefSeq Peptide - NP_995313
swissprot - D6RGX9
swissprot - Q6UWN8
Ensembl - ENSG00000178172
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPINK6ENSGALG00000032567Gallus gallus
 Q8BT20ENSMUSG00000055095Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0070268 cornification TAS
 biological_processGO:1900004 negative regulation of serine-type endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186474 KLK12 / Q9UKR0 / kallikrein related peptidase 12  / reaction / complex
 ENSG00000167759 KLK13 / Q9UKR3 / kallikrein related peptidase 13  / reaction / complex
 ENSG00000129437 KLK14 / Q9P0G3 / kallikrein related peptidase 14  / reaction / complex
 ENSG00000167754 KLK5 / Q9Y337 / kallikrein related peptidase 5  / reaction / complex






 

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