ENSG00000186474


Homo sapiens

Features
Gene ID: ENSG00000186474
  
Biological name :KLK12
  
Synonyms : kallikrein related peptidase 12 / KLK12 / Q9UKR0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.41
Gene start: 51029092
Gene end: 51035230
  
Corresponding Affymetrix probe sets: 220782_x_at (Human Genome U133 Plus 2.0 Array)   233586_s_at (Human Genome U133 Plus 2.0 Array)   234316_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434036
Ensembl peptide - ENSP00000436458
Ensembl peptide - ENSP00000436121
Ensembl peptide - ENSP00000434604
Ensembl peptide - ENSP00000434339
Ensembl peptide - ENSP00000250351
Ensembl peptide - ENSP00000324181
NCBI entrez gene - 43849     See in Manteia.
OMIM - 605539
RefSeq - XM_005258951
RefSeq - NM_019598
RefSeq - NM_145894
RefSeq - NM_145895
RefSeq - XM_005258950
RefSeq Peptide - NP_665901
RefSeq Peptide - NP_665902
RefSeq Peptide - NP_062544
swissprot - Q9UKR0
swissprot - A0A024R4M4
swissprot - E9PR22
swissprot - E9PPC6
Ensembl - ENSG00000186474
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000034771Gallus gallus
 Klk12ENSMUSG00000044430Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLK10 / O43240 / kallikrein related peptidase 10ENSG0000012945142
KLK5 / Q9Y337 / kallikrein related peptidase 5ENSG0000016775442
KLK7 / P49862 / kallikrein related peptidase 7ENSG0000016903541
KLK4 / Q9Y5K2 / kallikrein related peptidase 4ENSG0000016774938


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space NAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity NAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000178172 Q6UWN8 / SPINK6 / serine peptidase inhibitor, Kazal type 6  / reaction / complex






 

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