ENSG00000142615


Homo sapiens

Features
Gene ID: ENSG00000142615
  
Biological name :CELA2A
  
Synonyms : CELA2A / chymotrypsin like elastase family member 2A / P08217
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.21
Gene start: 15456728
Gene end: 15472091
  
Corresponding Affymetrix probe sets: 206446_s_at (Human Genome U133 Plus 2.0 Array)   206447_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000352639
NCBI entrez gene - 63036     See in Manteia.
OMIM - 609443
RefSeq - NM_033440
RefSeq Peptide - NP_254275
swissprot - P08217
Ensembl - ENSG00000142615
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ela2ENSDARG00000056744Danio rerio
 ela2lENSDARG00000056765Danio rerio
 CELA2AENSGALG00000004568Gallus gallus
 Cela2aENSMUSG00000058579Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CELA2B / P08218 / chymotrypsin like elastase family member 2BENSG0000021570488
CTRC / Q99895 / chymotrypsin CENSG0000016243862
CELA3B / P08861 / chymotrypsin like elastase family member 3BENSG0000021907358
CELA3A / P09093 / chymotrypsin like elastase family member 3AENSG0000014278957
CELA1 / Q9UNI1 / chymotrypsin like elastase family member 1ENSG0000013961054
CTRL / P40313 / chymotrypsin likeENSG0000014108645
CTRB1 / P17538 / chymotrypsinogen B1ENSG0000016892541
CTRB2 / Q6GPI1 / chymotrypsinogen B2ENSG0000016892840
OVCH2 / ovochymase 2 (gene/pseudogene)ENSG0000018337833
OVCH1 / Q7RTY7 / ovochymase 1ENSG0000018795033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0036457 keratohyalin granule IDA
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017171 serine hydrolase activity IDA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167754 KLK5 / Q9Y337 / kallikrein related peptidase 5  / reaction
 ENSG00000143631 FLG / P20930 / filaggrin  / reaction






 

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