ENSMUSG00000026639


Mus musculus

Features
Gene ID: ENSMUSG00000026639
  
Biological name :Lamb3
  
Synonyms : Lamb3 / Laminin subunit beta-3 / Q61087
  
Possible biological names infered from orthology : Q13751
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H6
Gene start: 193207699
Gene end: 193343878
  
Corresponding Affymetrix probe sets: 10352838 (MoGene1.0st)   1417812_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016315
Ensembl peptide - ENSMUSP00000123875
Ensembl peptide - ENSMUSP00000141302
Ensembl peptide - ENSMUSP00000142053
NCBI entrez gene - 16780     See in Manteia.
MGI - MGI:99915
RefSeq - XM_006497233
RefSeq - NM_001277928
RefSeq - NM_008484
RefSeq - XM_006497232
RefSeq Peptide - NP_032510
RefSeq Peptide - NP_001264857
swissprot - Q61087
swissprot - A0A0A6YVX1
Ensembl - ENSMUSG00000026639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01092781.1ENSDARG00000110040Danio rerio
 LAMB3ENSGALG00000001343Gallus gallus
 LAMB3ENSG00000196878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291135
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290034
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564722
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442119
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989919
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647818
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684018
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279618
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG0000002001917
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG0000002647911
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG000000198469


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005610 laminin-5 complex IDA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Assembly of collagen fibrils and other multimeric structures
Anchoring fibril formation
Laminin interactions
Type I hemidesmosome assembly
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Lamb3tm1.1Hosc/Lamb3tm1.1Hosc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0002251 abnormal nasopharynx morphology "structural anomaly of the section of the pharynx that lies above the soft palate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0002252 abnormal oropharynx morphology "structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb3tm1.1Hosc/Lamb3tm1.1Hosc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lamb3tm1.1Hosc/Lamb3tm1.1Hosc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lamb3tm1.1Hosc/Lamb3tm1.1Hosc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011159 abnormal epidermal-dermal junction morphology "any structural anomaly of the multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction" [PMID:1097542]
Show

Allelic Composition: Lamb3tm1.1Hosc/Lamb3tm1.1Hosc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011160 dermal-epidermal separation "the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis" [MGI:csmith]
Show

Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / reaction / complex
 ENSMUSG00000020758 Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / complex / reaction
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / complex
 ENSMUSG00000025064 Q07563 / Col17a1 / Collagen alpha-1(XVII) chain 120 kDa linear IgA disease antigen homolog / Q9UMD9* / collagen type XVII alpha 1 chain*  / complex / reaction
 ENSMUSG00000015533 Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*  / complex / reaction
 ENSMUSG00000016942 Q9DBI0 / Tmprss6 / Mus musculus transmembrane serine protease 6 (Tmprss6), transcript variant 2, mRNA. / Q8IU80* / transmembrane serine protease 6*  / reaction
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / complex
 ENSMUSG00000022565 Plec / Q9QXS1 / plectin / Q15149*  / reaction / complex
 ENSMUSG00000025510 Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*  / reaction / complex
 ENSMUSG00000026131 Dst / Q91ZU6 / Dystonin / Q03001*  / reaction / complex
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / reaction






 

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