ENSMUSG00000019846


Mus musculus

Features
Gene ID: ENSMUSG00000019846
  
Biological name :Lama4
  
Synonyms : Lama4 / Laminin subunit alpha-4 / P97927
  
Possible biological names infered from orthology : Q16363
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B1
Gene start: 38965515
Gene end: 39110188
  
Corresponding Affymetrix probe sets: 10362538 (MoGene1.0st)   1424807_at (Mouse Genome 430 2.0 Array)   1424808_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019992
NCBI entrez gene - 16775     See in Manteia.
MGI - MGI:109321
RefSeq - NM_010681
RefSeq Peptide - NP_034811
swissprot - P97927
Ensembl - ENSMUSG00000019846
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lama4ENSDARG00000020785Danio rerio
 ENSGALG00000015001Gallus gallus
 LAMA4ENSG00000112769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564727
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442127
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989923
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279621
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290010
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291110
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG000000264789
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG000000264798
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG000000268408
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG000000266396
Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*ENSMUSG000000200193


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR002049  Laminin EGF domain
 IPR009254  Laminin alpha, domain I
 IPR010307  Laminin domain II
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0045995 regulation of embryonic development IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane ISO
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Laminin interactions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001569 abnormal circulating bilirubin level "aberrant concentration in the blood of this yellow heme breakdown product " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Btkxid/Btkxid
Genetic Background: CBA/HN-Btkxid

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Mrl/Nos2tm1Mrl,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003044 impaired basement membrane formation "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0004120 cardiac ischemia "inadequate blood blow to the heart; may cause infarction and is usually caused by coronary artery disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0004122 sinus arrhythmia "irregular heartbeat related to abnormal function of the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0004273 abnormal basal lamina morphology "anomaly in the structure of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry,Tg(ACTB-Lama5)1Jhm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/ReJ-Lama2dy/J

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020326 dilated capillary "stretched or widened aperture of the luminal space of the small branching blood vessel that form a network between the arterioles and venules" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

 MP:0020452 abnormal axon radial sorting "any anomaly in the process by which immature Schwann cells surround axons of mixed caliber and send cytoplasmic processes that resemble lamellipodia between axons, to progressively choose and segregate the larger axons at the periphery of the bundle" [MGI:smb, PMID:25686621]
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Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: B6.129X1-Lama4tm1Ktry

Allelic Composition: Lama2tm1Stk/Lama2tm1Stk,Lama4tm1Ktry/Lama4tm1Ktry
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052911 Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*  / complex
 ENSMUSG00000026840 Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*  / complex
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / complex
 ENSMUSG00000026478 Lamc1 / laminin subunit gamma 1 / P11047*  / complex






 

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