MP:0000172 | abnormal bone marrow cell number | "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc] |
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Allelic Composition: Alx4tm1Rwi/Alx4+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm
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MP:0001218 | thin epidermis | "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
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MP:0002053 | decreased incidence of induced tumors | "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886] |
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+ Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
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MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
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MP:0002828 | abnormal glomerular capsule | "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm
Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm
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MP:0003544 | abnormal vascular endothelial cell migration | "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387] |
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+ Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
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MP:0003606 | kidney failure | "cessation of renal function" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0004003 | abnormal vascular endothelial cell physiology | "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+ Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
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MP:0004502 | decreased incidence of chemically-induced tumors | "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm
Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm
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MP:0004756 | abnormal proximal convoluted tubule morphology | "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0004970 | kidney atrophy | "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0005094 | abnormal T cell proliferation | "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Alx4tm1Rwi/Alx4+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0005602 | decreased angiogenesis | "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hoxa10tm1Ipc/Hoxa10+ Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
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MP:0005606 | increased bleeding time | "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Alx4tm1Rwi/Alx4+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0008061 | absent podocyte slit diaphragm | "absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0008138 | absent podocyte foot process | "absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0008140 | podocyte foot process effacement | "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0009050 | dilated proximal convoluted tubules | "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0009584 | decreased keratinocyte proliferation | "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Marveld2tm1.1Sria/Marveld2+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm
Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Itga3tm1Son/Itga3+,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm
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MP:0009641 | kidney degeneration | "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0011320 | abnormal glomerular capillary morphology | "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0011348 | abnormal renal glomerulus basement membrane morphology | "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0011353 | expanded mesangial matrix | "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0011402 | renal cast | "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0011405 | tubulointerstitial nephritis | "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0011409 | increased renal glomerulus basement membrane thickness | "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0011427 | mesangial cell hyperplasia | "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0011453 | abnormal glomerular capillary endothelium morphology | "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0011454 | abnormal glomerular endothelium fenestra morphology | "any structural anomaly of the large plasma membrane-lined circular pores that perforate the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, are not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0011483 | renal glomerular synechia | "presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0011506 | glomerular crescent | "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
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MP:0011534 | granular kidney | "a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis" [MGI:anna] |
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Allelic Composition: Il12btm1Jm/Il12btm1Jm Genetic Background: 129S1/Sv-Il12btm1Jm
Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0011753 | decreased podocyte number | "reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [MGI:anna] |
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Allelic Composition: Cd151tm1Lka/Cd151tm1Lka Genetic Background: FVB.B6-CD151tm1Lka
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MP:0012193 | increased keratinocyte migration | "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith] |
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Allelic Composition: Cd151tm2Nki/Cd151tm2Nki,Krt14tm1(cre)Wbm/? Genetic Background: FVB.129P2-Cd151tm2Nki Krt14tm1(cre)Wbm
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MP:0012194 | decreased keratinocyte migration | "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith] |
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Allelic Composition: Alx4tm1Rwi/Alx4+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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