ENSMUSG00000025351


Mus musculus

Features
Gene ID: ENSMUSG00000025351
  
Biological name :Cd63
  
Synonyms : Cd63 / CD63 antigen / P41731
  
Possible biological names infered from orthology : CD63 molecule / P08962
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128900989
Gene end: 128912822
  
Corresponding Affymetrix probe sets: 10367436 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000026407
Ensembl peptide - ENSMUSP00000100862
Ensembl peptide - ENSMUSP00000151313
Ensembl peptide - ENSMUSP00000151955
NCBI entrez gene - 12512     See in Manteia.
MGI - MGI:99529
RefSeq - NM_001042580
RefSeq - NM_001282966
RefSeq - NM_007653
RefSeq Peptide - NP_001036045
RefSeq Peptide - NP_001269895
RefSeq Peptide - NP_031679
swissprot - Q549D0
swissprot - A0A1W2P8C6
swissprot - P41731
Ensembl - ENSMUSG00000025351
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd63ENSDARG00000025147Danio rerio
 CD63ENSG00000135404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QY33 / Tspan3 / tetraspanin 3 / O60637*ENSMUSG0000003232432
Q8QZY6 / Tspan14 / Tetraspanin-14 / Q8NG11*ENSMUSG0000003782430
Q62283 / Tspan7 / tetraspanin 7 / P41732* / AF241726.2*ENSMUSG0000005825429
Q8R3S2 / Tspan33 / Tetraspanin-33 / Q86UF1*ENSMUSG0000000176329
Tspan17 / tetraspanin 17 / Q96FV3*ENSMUSG0000002587529
Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*ENSMUSG0000002551028
P62080 / Tspan5 / tetraspanin 5 / P62079*ENSMUSG0000002815227
Tspan6 / tetraspanin 6 / O43657*ENSMUSG0000006737727
F7BWT7 / Tspan15 / Tetraspanin-15 / O95858*ENSMUSG0000003703125
Q9D1D1 / Tspan11 / Tetraspanin-11 / A1L157*ENSMUSG0000003035123
Tspan10 / tetraspanin 10ENSMUSG0000003969122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000301  Tetraspanin
 IPR008952  Tetraspanin, EC2 domain superfamily
 IPR018499  Tetraspanin/Peripherin
 IPR018503  Tetraspanin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization ISS
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007160 cell-matrix adhesion ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0034613 cellular protein localization ISO
 biological_processGO:0035646 endosome to melanosome transport ISS
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0045807 positive regulation of endocytosis IBA
 biological_processGO:0048757 pigment granule maturation ISO
 biological_processGO:0050931 pigment cell differentiation IMP
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IMP
 biological_processGO:1901379 regulation of potassium ion transmembrane transport ISO
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0010008 endosome membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISO
 cellular_componentGO:0031902 late endosome membrane ISO
 cellular_componentGO:0031904 endosome lumen ISO
 cellular_componentGO:0032585 multivesicular body membrane ISO
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0097487 multivesicular body, internal vesicle ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0011757 abnormal kidney collecting duct principal cell morphology "any structural abnormality of the cuboidal epithelial cells found in the collecting ducts of the kidney which regulate sodium and potassium balance via channels located on the cells apical membrane. Aldosterone increases the number of Na+/K+-ATPase pumps that allow increased sodium reabsorption and potassium secretion whereas antidiuretic hormone (vasopressin) determines the expression of aquaporin channels on the cell surface; together, aldosterone and vasopressin let the principal cell control the quantity of water that is reabsorbed" [MGI:anna]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,E2f3tm3Lees/E2f3tm3Lees
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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