ENSMUSG00000001763


Mus musculus

Features
Gene ID: ENSMUSG00000001763
  
Biological name :Tspan33
  
Synonyms : Q8R3S2 / Tetraspanin-33 / Tspan33
  
Possible biological names infered from orthology : Q86UF1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.3
Gene start: 29694222
Gene end: 29718559
  
Corresponding Affymetrix probe sets: 10536908 (MoGene1.0st)   1425157_x_at (Mouse Genome 430 2.0 Array)   1451608_a_at (Mouse Genome 430 2.0 Array)   1451609_at (Mouse Genome 430 2.0 Array)   1455618_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045282
Ensembl peptide - ENSMUSP00000110905
NCBI entrez gene - 232670     See in Manteia.
MGI - MGI:1919012
RefSeq - NM_001301407
RefSeq - NM_146173
RefSeq Peptide - NP_001288336
RefSeq Peptide - NP_666285
swissprot - Q8R3S2
Ensembl - ENSMUSG00000001763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5RH71ENSDARG00000004497Danio rerio
 Q86UF1ENSG00000158457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tspan17 / tetraspanin 17 / Q96FV3*ENSMUSG0000002587542
P62080 / Tspan5 / tetraspanin 5 / P62079*ENSMUSG0000002815240
Q8QZY6 / Tspan14 / Tetraspanin-14 / Q8NG11*ENSMUSG0000003782437
F7BWT7 / Tspan15 / Tetraspanin-15 / O95858*ENSMUSG0000003703135
Tspan10 / tetraspanin 10ENSMUSG0000003969130
Q9D1D1 / Tspan11 / Tetraspanin-11 / A1L157*ENSMUSG0000003035127
Cd151 / O35566 / CD151 antigen / P48509* / CD151 molecule (Raph blood group)*ENSMUSG0000002551025
Cd63 / P41731 / CD63 antigen / P08962* / CD63 molecule*ENSMUSG0000002535124
Q62283 / Tspan7 / tetraspanin 7 / P41732* / AF241726.2*ENSMUSG0000005825424
Q9QY33 / Tspan3 / tetraspanin 3 / O60637*ENSMUSG0000003232423
Tspan6 / tetraspanin 6 / O43657*ENSMUSG0000006737722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000301  Tetraspanin
 IPR008952  Tetraspanin, EC2 domain superfamily
 IPR018499  Tetraspanin/Peripherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0051604 protein maturation IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097197 tetraspanin-enriched microdomain IDA
 molecular_functionGO:0019899 enzyme binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0010175 leptocytosis "the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull s-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-12DTR/Oca2p-12DTR
Genetic Background: involves: 101/Rl * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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