| MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0003461 | abnormal response to novel object | "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0004753 | abnormal miniature excitatory postsynaptic currents | "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0005402 | abnormal action potential | "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0008428 | abnormal spatial working memory | "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0009454 | impaired contextual conditioning | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0009939 | abnormal hippocampus neuron morphology | |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0012307 | impaired spatial learning | "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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| MP:0020508 | decreased dendritic spine density | "decrease in the number of dendritic spines in a given cross-sectional area of a dendrite" [MGI:smb] |
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J
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