ENSMUSG00000000957


Mus musculus

Features
Gene ID: ENSMUSG00000000957
  
Biological name :Mmp14
  
Synonyms : Matrix metalloproteinase-14 / Mmp14 / P53690
  
Possible biological names infered from orthology : matrix metallopeptidase 14 / P50281
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C2
Gene start: 54431612
Gene end: 54445364
  
Corresponding Affymetrix probe sets: 10415052 (MoGene1.0st)   1416572_at (Mouse Genome 430 2.0 Array)   1440920_at (Mouse Genome 430 2.0 Array)   1448383_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087119
Ensembl peptide - ENSMUSP00000153679
Ensembl peptide - ENSMUSP00000143012
Ensembl peptide - ENSMUSP00000142665
NCBI entrez gene - 17387     See in Manteia.
MGI - MGI:101900
RefSeq - NM_008608
RefSeq Peptide - NP_032634
swissprot - A0A0G2JF39
swissprot - A0A0G2JE78
swissprot - A0A286YED2
swissprot - P53690
Ensembl - ENSMUSG00000000957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp14aENSDARG00000002235Danio rerio
 mmp14bENSDARG00000008388Danio rerio
 MMP14ENSG00000157227Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179057
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822655
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761254
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390335
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943633
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756231
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361331
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580030
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032330
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057830
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862030
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308928
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972328
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090128
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162027
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028693  Matrix metalloproteinase-14
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0001958 endochondral ossification IGI
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010831 positive regulation of myotube differentiation IMP
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030574 collagen catabolic process IGI
 biological_processGO:0031638 zymogen activation IMP
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0035988 chondrocyte proliferation IGI
 biological_processGO:0043615 astrocyte cell migration IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly IEA
 biological_processGO:0060322 head development IMP
 biological_processGO:0060348 bone development IGI
 biological_processGO:0097094 craniofacial suture morphogenesis IGI
 biological_processGO:1905523 positive regulation of macrophage migration IMP
 biological_processGO:1990834 response to odorant IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0044354 macropinosome IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000084 abnormal fontanelle morphology "structural defect in the membranous interval at the margins of cranial bones in neonates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0000098 abnormal vomer bone morphology "missing triangular flat bone of the nasal septum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000103 nasal bone hypoplasia "reduced cell number in the bone which forms the nasal bridge" [J:53370]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000440 domed skull 
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14m1Btlr/Mmp14m1Btlr
Genetic Background: C57BL/6J-Mmp14m1Btlr

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000457 maxilla hypoplasia "arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000736 delayed muscle development "late onset of the induction and/or differentiation of skeletal muscle" [J:18048]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Nr5a1tm3Klp/Nr5a1tm3Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14m1Btlr/Mmp14m1Btlr
Genetic Background: C57BL/6J-Mmp14m1Btlr

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001296 macrophthalmia "increased average size of the eyes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14m1Btlr/Mmp14m1Btlr
Genetic Background: C57BL/6J-Mmp14m1Btlr

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Mmp14m1Btlr/Mmp14m1Btlr
Genetic Background: C57BL/6J-Mmp14m1Btlr

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

Allelic Composition: Mmp14m1Btlr/Mmp14m1Btlr
Genetic Background: C57BL/6J-Mmp14m1Btlr

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mlphln-Btlr/Mlphln-Btlr
Genetic Background: C57BL/6J-Mlphln-Btlr

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002268 abnormal terminal bronchiole morphology "any structural anomaly of the last conducting structure of bronchioles; after this point, the airways have alveoli in their walls " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnk5Gt(pGT1.8TM)1Gray/Kcnk5Gt(pGT1.8TM)1Gray
Genetic Background: B6.129P2-Kcnk5Gt(pGT1.8TM)1Gray

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0002835 abnormal cranial suture morphology "defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003053 delayed tooth eruption "postponed onset of the growth of the teeth out of the gums" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003379 absent sexual maturation "failure to initiate pubertal changes that result in achievement of full sexual capacity" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004420 parietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004455 pterygoid bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004476 absent palatine bone "absence of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0004830 short incisors "reduced length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0004869 frontal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone which forms the forehead and roof of the eye orbit" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0005421 loose skin "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

Allelic Composition: Mmp14m1Btlr/Mmp14m1Btlr
Genetic Background: C57BL/6J-Mmp14m1Btlr

 MP:0008526 decreased skull width "having a decreased side-to-side distance of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0008529 enlarged optic nerve "increased size of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1.1Khol,Mmp15tm1Kohl/Mmp15tm1Kohl,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0009520 decreased submandibular gland size "reduced size of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009900 vomer bone hypoplasia "underdevelopment of the vomer bone, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0010030 abnormal orbit morphology "any structural anomaly of the bony ring that supports the eyeball and supporting tissues and is formed by parts of several cranial bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0010743 delayed suture closure "late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0010809 abnormal Clara cell morphology "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010870 absent bone trabeculae "absence of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0010905 absent alveolar pores "absence of the openings in the alveolar septum that permit air flow between adjacent alveoli" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010908 dilated pulmonary alveolar ducts "expansion or widening of the lumens of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mmp14m1Btlr/Mmp14m1Btlr
Genetic Background: C57BL/6J-Mmp14m1Btlr

 MP:0011156 abnormal hypodermis fat layer morphology "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]
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Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011360 kidney cortex hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the outer portion of the kidney, which contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts" [MGI:anna]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0011376 abnormal kidney corticomedullary boundary morphology "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Mmp14tm1Ski/Mmp14tm1Ski
Genetic Background: B6.Cg-Mmp14tm1Ski

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0013542 abnormal submandibular gland branching morphogenesis 
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0030009 increased bone marrow adipose tissue amount "increased quantity of the bone marrow fat-storing cells/tissue" [PMID:27094502]
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Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030077 small cranial cavity "reduced size of the space formed within the skull and occupied by the brain, pineal and hypophysis cerebri, parts of the cranial and spinal nerves, blood vessels, meninges and cerebrospinal fluid" [MGI:anna]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0030089 short lower incisors "reduced length of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0030090 short upper incisors "reduced length of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0030137 abnormal upper incisor morphology "any structural anomaly of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0030225 abnormal cranial vertex morphology "any structural anomaly of the midline bony landmark at the most superior part of the calvaria, near the midpoint of the sagittal suture (i.e. between the bregma and lambda)" [https://radiopaedia.org/articles/vertex]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: B6.129X1-Mmp14tm1Ktry

 MP:0030245 round head "overall shape of the head is more circular than usual as viewed from the front" [MGI:anna]
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Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

 MP:0030279 thin neurocranium "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14tm1Hbh,Mmp16tm1Khol/Mmp16+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp14tm1Hbh/Mmp14+,Mmp16tm1Khol/Mmp16tm1Khol
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000050578 Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*  / reaction
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / complex / reaction
 ENSMUSG00000017466 Timp2 / tissue inhibitor of metalloproteinase 2 / P16035* / TIMP metallopeptidase inhibitor 2*  / reaction / complex
 ENSMUSG00000019929 Dcn / P28654 / Decorin / P07585*  / reaction
 ENSMUSG00000028763 Hspg2 / perlecan (heparan sulfate proteoglycan 2) / P98160* / heparan sulfate proteoglycan 2*  / reaction
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / reaction
 ENSMUSG00000026639 Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*  / reaction
 ENSMUSG00000026479 Lamc2 / laminin subunit gamma 2 / Q13753*  / reaction
 ENSMUSG00000024421 Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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