Manteia

ENSDARG00000002235

Danio rerio

Features

Gene ID:	ENSDARG00000002235

Biological name :	mmp14a

Synonyms :	matrix metallopeptidase 14a (membrane-inserted) / mmp14a

Possible biological names infered from orthology :	matrix metallopeptidase 14 / Matrix metalloproteinase-14 / MMP14 / P50281 / P53690

Species:	Danio rerio

Chr. number:	7
Strand:	-1
Band:
Gene start:	24124289
Gene end:	24149670

Corresponding Affymetrix probe sets:	Dr.25553.1.A1_at (Zebrafish Array) Dr.4229.1.S1_at (Zebrafish Array) NM_194416_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000019511 NCBI entrez gene - 373882 See in Manteia. RefSeq - NM_194416 RefSeq Peptide - NP_919397 swissprot - F1Q899 ZFIN ID - ZDB-GENE-030901-1 Ensembl - ENSDARG00000002235

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
MMP14	ENSG00000157227	Homo sapiens
Mmp14	ENSMUSG00000000957	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *	ENSDARG00000008388	70
mmp15b / matrix metallopeptidase 15b / MMP15* / P51511* / matrix metallopeptidase 15*	ENSDARG00000013072	56
mmp24 / matrix metallopeptidase 24 / Q9R0S2* / Q9Y5R2* / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24*	ENSDARG00000018896	51
mmp15a / matrix metallopeptidase 15a / MMP15* / O54732* / P51511* / matrix metallopeptidase 15* / Matrix metalloproteinase-15 *	ENSDARG00000051962	50
mmp16b / matrix metallopeptidase 16b (membrane-inserted) / MMP16* / P51512* / Q9WTR0* / matrix metallopeptidase 16* / Matrix metalloproteinase-16 *	ENSDARG00000058876	49
mmp25b / matrix metallopeptidase 25b / MMP25* / Q9NPA2* / matrix metallopeptidase 25*	ENSDARG00000010556	33
mmp17a / matrix metallopeptidase 17a / MMP17* / Q9R0S3* / Q9ULZ9* / matrix metallopeptidase 17* / Matrix metalloproteinase-17 *	ENSDARG00000078915	30
mmp25a / matrix metallopeptidase 25a / MMP25* / Q3U435* / Q9NPA2* / matrix metallopeptidase 25* / Matrix metalloproteinase-25 *	ENSDARG00000077290	30
mmp13a / matrix metallopeptidase 13a	ENSDARG00000114451	28
mmp11a / matrix metallopeptidase 11a / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*	ENSDARG00000026325	28
mmp11b / matrix metallopeptidase 11b / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*	ENSDARG00000016718	28
mmp30 / matrix metallopeptidase 30 / MMP7* / P09237* / matrix metallopeptidase 7*	ENSDARG00000045887	28
mmp13b / matrix metallopeptidase 13b / MMP13* / P45452* / P33435* / Collagenase 3 * / matrix metallopeptidase 13*	ENSDARG00000100794	28
mmp13a / matrix metallopeptidase 13a	ENSDARG00000012395	28
mmp20b / matrix metallopeptidase 20b (enamelysin)	ENSDARG00000055479	25
LO018336.1	ENSDARG00000108401	25
mmp20a / matrix metallopeptidase 20a (enamelysin) / MMP20* / O60882* / P57748* / matrix metallopeptidase 20* / Matrix metalloproteinase-20 *	ENSDARG00000089887	25
mmp17b / matrix metallopeptidase 17b	ENSDARG00000102956	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR000585	Hemopexin-like domain
IPR001818	Peptidase M10, metallopeptidase
IPR002477	Peptidoglycan binding-like
IPR006026	Peptidase, metallopeptidase
IPR018486	Hemopexin, conserved site
IPR018487	Hemopexin-like repeats
IPR021158	Peptidase M10A, cysteine switch, zinc binding site
IPR021190	Peptidase M10A
IPR021805	Peptidase M10A, matrix metallopeptidase, C-terminal
IPR024079	Metallopeptidase, catalytic domain superfamily
IPR033739	Peptidase M10A, catalytic domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001666	response to hypoxia	IDA
biological_process	GO:0003407	neural retina development	IMP
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0009948	anterior/posterior axis specification	IMP
biological_process	GO:0010842	retina layer formation	IMP
biological_process	GO:0030010	establishment of cell polarity	IGI
biological_process	GO:0030307	positive regulation of cell growth	IEA
biological_process	GO:0030335	positive regulation of cell migration	IEA
biological_process	GO:0031290	retinal ganglion cell axon guidance	IMP
biological_process	GO:0042074	cell migration involved in gastrulation	IGI
biological_process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP
biological_process	GO:0051216	cartilage development	IMP
biological_process	GO:0060026	convergent extension	IGI
biological_process	GO:0060027	convergent extension involved in gastrulation	IMP
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0031012	extracellular matrix	IEA
molecular_function	GO:0004222	metalloendopeptidase activity	IEA
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008237	metallopeptidase activity	NAS
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Degradation of the extracellular matrix

Activation of Matrix Metalloproteinases

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000008	brain	brain apoptotic , abnormal brain morphology , abnormal	Show
ZFA:0000054	pericardium	pericardium edematous , abnormal	Show
ZFA:0000092	axis	axis decreased length , abnormal	Show
ZFA:0000106	extension	extension decreased length , abnormal	Show
ZFA:0000135	notochord	notochord increased width , abnormal	Show
ZFA:0001094	whole organism	whole organism decreased length , abnormal whole organism anterior-posterior axis deformed , abnormal	Show
ZFA:0001216	splanchnocranium	splanchnocranium morphology , abnormal	Show
ZFA:0001424	chondrocranium	chondrocranium morphology , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr