ENSDARG00000008388


Danio rerio

Features
Gene ID: ENSDARG00000008388
  
Biological name :mmp14b
  
Synonyms : matrix metallopeptidase 14b (membrane-inserted) / mmp14b
  
Possible biological names infered from orthology : matrix metallopeptidase 14 / Matrix metalloproteinase-14 / MMP14 / P50281 / P53690
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 38161318
Gene end: 38183641
  
Corresponding Affymetrix probe sets: Dr.23324.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000044263
NCBI entrez gene - 566945     See in Manteia.
RefSeq - NM_194414
RefSeq Peptide - NP_919395
swissprot - B0R0I1
ZFIN ID - ZDB-GENE-030901-2
Ensembl - ENSDARG00000008388
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMP14ENSG00000157227Homo sapiens
 Mmp14ENSMUSG00000000957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mmp14a / matrix metallopeptidase 14a (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *ENSDARG0000000223565
mmp15b / matrix metallopeptidase 15b / MMP15* / P51511* / matrix metallopeptidase 15*ENSDARG0000001307253
mmp24 / matrix metallopeptidase 24 / Q9R0S2* / Q9Y5R2* / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24*ENSDARG0000001889648
mmp15a / matrix metallopeptidase 15a / MMP15* / O54732* / P51511* / matrix metallopeptidase 15* / Matrix metalloproteinase-15 *ENSDARG0000005196247
mmp16b / matrix metallopeptidase 16b (membrane-inserted) / MMP16* / P51512* / Q9WTR0* / matrix metallopeptidase 16* / Matrix metalloproteinase-16 *ENSDARG0000005887646
mmp25b / matrix metallopeptidase 25b / MMP25* / Q9NPA2* / matrix metallopeptidase 25*ENSDARG0000001055632
mmp25a / matrix metallopeptidase 25a / MMP25* / Q3U435* / Q9NPA2* / matrix metallopeptidase 25* / Matrix metalloproteinase-25 *ENSDARG0000007729029
mmp17a / matrix metallopeptidase 17a / MMP17* / Q9R0S3* / Q9ULZ9* / matrix metallopeptidase 17* / Matrix metalloproteinase-17 *ENSDARG0000007891528
mmp13b / matrix metallopeptidase 13b / MMP13* / P45452* / P33435* / Collagenase 3 * / matrix metallopeptidase 13*ENSDARG0000010079427
mmp13a / matrix metallopeptidase 13aENSDARG0000011445127
mmp13a / matrix metallopeptidase 13aENSDARG0000001239527
mmp11a / matrix metallopeptidase 11a / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*ENSDARG0000002632526
mmp30 / matrix metallopeptidase 30 / MMP7* / P09237* / matrix metallopeptidase 7*ENSDARG0000004588726
mmp11b / matrix metallopeptidase 11b / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*ENSDARG0000001671825
mmp20a / matrix metallopeptidase 20a (enamelysin) / MMP20* / O60882* / P57748* / matrix metallopeptidase 20* / Matrix metalloproteinase-20 *ENSDARG0000008988724
mmp20b / matrix metallopeptidase 20b (enamelysin)ENSDARG0000005547924
mmp17b / matrix metallopeptidase 17bENSDARG0000010295624
LO018336.1ENSDARG0000010840123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033739  Peptidase M10A, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0009948 anterior/posterior axis specification IMP
 biological_processGO:0030010 establishment of cell polarity IGI
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060026 convergent extension IGI
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity NAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
Show

 ZFA:0000092 axis axis decreased length , abnormal
axis increased width , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
Show

 ZFA:0000109 forebrain forebrain increased width , abnormal
Show

 ZFA:0000135 notochord notochord increased width , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
Show

 ZFA:0001064 rhombomere rhombomere increased width , abnormal
Show

 ZFA:0001065 lateral mesoderm lateral mesoderm morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism morphology , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
Show

 ZFA:0001500 auditory capsule auditory capsule morphology , abnormal
Show

 ZFA:0009138 mesodermal cell mesodermal cell circular , abnormal
mesodermal cell disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008388 mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *  / reaction
 ENSDARG00000075261 timp2b / TIMP metallopeptidase inhibitor 2b / TIMP2* / P16035* / TIMP metallopeptidase inhibitor 2*  / reaction / complex
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr