ENSDARG00000075261


Danio rerio

Features
Gene ID: ENSDARG00000075261
  
Biological name :timp2b
  
Synonyms : timp2b / TIMP metallopeptidase inhibitor 2b
  
Possible biological names infered from orthology : P16035 / TIMP2 / TIMP metallopeptidase inhibitor 2 / tissue inhibitor of metalloproteinase 2
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 57632965
Gene end: 57666996
  
Corresponding Affymetrix probe sets: Dr.15281.1.A1_at (Zebrafish Array)   Dr.22985.1.A1_at (Zebrafish Array)   NM_213296_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000092838
Ensembl peptide - ENSDARP00000141124
NCBI entrez gene - 406650     See in Manteia.
RefSeq - NM_213296
RefSeq Peptide - NP_998461
swissprot - F6NH88
swissprot - Q6NUX9
ZFIN ID - ZDB-GENE-040426-2655
Ensembl - ENSDARG00000075261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIMP2ENSGALG00000027070Gallus gallus
 TIMP2ENSG00000035862Homo sapiens
 Timp2ENSMUSG00000017466Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
timp2a / TIMP metallopeptidase inhibitor 2a / TIMP2* / P16035* / TIMP metallopeptidase inhibitor 2* / tissue inhibitor of metalloproteinase 2*ENSDARG0000006122651
timp4.1 / TIMP metallopeptidase inhibitor 4, tandem duplicate 1 / TIMP4* / Q99727* / TIMP metallopeptidase inhibitor 4*ENSDARG0000011180523
timp4.2 / TIMP metallopeptidase inhibitor 4, tandem duplicate 2ENSDARG0000010261715
timp4.3 / TIMP metallopeptidase inhibitor 4, tandem duplicate 3ENSDARG0000010079514


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015613  Metalloproteinase inhibitor 2
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009725 response to hormone IBA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0043086 negative regulation of catalytic activity IBA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008388 mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *  / reaction / complex






 

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