ENSG00000035862


Homo sapiens

Features
Gene ID: ENSG00000035862
  
Biological name :TIMP2
  
Synonyms : P16035 / TIMP2 / TIMP metallopeptidase inhibitor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 78852977
Gene end: 78925387
  
Corresponding Affymetrix probe sets: 203167_at (Human Genome U133 Plus 2.0 Array)   224560_at (Human Genome U133 Plus 2.0 Array)   231579_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464930
Ensembl peptide - ENSP00000468296
Ensembl peptide - ENSP00000467584
Ensembl peptide - ENSP00000262768
Ensembl peptide - ENSP00000441724
NCBI entrez gene - 7077     See in Manteia.
OMIM - 188825
RefSeq - NM_003255
RefSeq Peptide - NP_003246
swissprot - B4DFW2
swissprot - A0A140VK57
swissprot - K7EIX4
swissprot - P16035
Ensembl - ENSG00000035862
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timp2aENSDARG00000061226Danio rerio
 timp2bENSDARG00000075261Danio rerio
 TIMP2ENSGALG00000027070Gallus gallus
 Timp2ENSMUSG00000017466Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIMP4 / Q99727 / TIMP metallopeptidase inhibitor 4ENSG0000015715047
TIMP3 / P35625 / TIMP metallopeptidase inhibitor 3ENSG0000010023442
TIMP1 / P01033 / TIMP metallopeptidase inhibitor 1ENSG0000010226525


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015613  Metalloproteinase inhibitor 2
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009725 response to hormone IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0032487 regulation of Rap protein signal transduction IEA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045762 positive regulation of adenylate cyclase activity IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IBA
 biological_processGO:1905049 negative regulation of metallopeptidase activity IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087245 MMP2 / P08253 / matrix metallopeptidase 2  / complex / reaction
 ENSG00000157227 MMP14 / P50281 / matrix metallopeptidase 14  / reaction / complex






 

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