ENSG00000102265


Homo sapiens

Features
Gene ID: ENSG00000102265
  
Biological name :TIMP1
  
Synonyms : P01033 / TIMP1 / TIMP metallopeptidase inhibitor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.3
Gene start: 47582313
Gene end: 47586789
  
Corresponding Affymetrix probe sets: 201666_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366216
Ensembl peptide - ENSP00000406671
Ensembl peptide - ENSP00000410983
Ensembl peptide - ENSP00000218388
Ensembl peptide - ENSP00000405380
NCBI entrez gene - 7076     See in Manteia.
OMIM - 305370
RefSeq - XM_017029766
RefSeq - NM_003254
RefSeq Peptide - NP_003245
swissprot - P01033
swissprot - Q5H9A7
swissprot - Q5H9B4
swissprot - Q5H9B5
swissprot - Q6FGX5
swissprot - H0Y789
Ensembl - ENSG00000102265
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Timp1ENSMUSG00000001131Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIMP2 / P16035 / TIMP metallopeptidase inhibitor 2ENSG0000003586226
TIMP3 / P35625 / TIMP metallopeptidase inhibitor 3ENSG0000010023425
TIMP4 / Q99727 / TIMP metallopeptidase inhibitor 4ENSG0000015715024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015611  Metalloproteinase inhibitor 1
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001775 cell activation IEA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009725 response to hormone IBA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:1901164 negative regulation of trophoblast cell migration IMP
 biological_processGO:1905049 negative regulation of metallopeptidase activity IDA
 biological_processGO:2001044 regulation of integrin-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100985 MMP9 / P14780 / matrix metallopeptidase 9  / complex / reaction






 

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