ENSMUSG00000001131


Mus musculus

Features
Gene ID: ENSMUSG00000001131
  
Biological name :Timp1
  
Synonyms : Metalloproteinase inhibitor 1 / P12032 / Timp1
  
Possible biological names infered from orthology : P01033 / TIMP metallopeptidase inhibitor 1
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.3
Gene start: 20870166
Gene end: 20874735
  
Corresponding Affymetrix probe sets: 10598976 (MoGene1.0st)   1460227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009530
Ensembl peptide - ENSMUSP00000110999
NCBI entrez gene - 21857     See in Manteia.
MGI - MGI:98752
RefSeq - NM_001294280
RefSeq - NM_001044384
RefSeq - NM_011593
RefSeq Peptide - NP_001037849
RefSeq Peptide - NP_001281209
RefSeq Peptide - NP_035723
swissprot - P12032
Ensembl - ENSMUSG00000001131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIMP1ENSG00000102265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Timp3 / P39876 / tissue inhibitor of metalloproteinase 3 / P35625* / TIMP metallopeptidase inhibitor 3*ENSMUSG0000002004423
Timp4 / Q9JHB3 / tissue inhibitor of metalloproteinase 4 / Q99727* / TIMP metallopeptidase inhibitor 4*ENSMUSG0000003031723
Timp2 / tissue inhibitor of metalloproteinase 2 / P16035* / TIMP metallopeptidase inhibitor 2*ENSMUSG0000001746620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015611  Metalloproteinase inhibitor 1
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0009725 response to hormone IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity ISS
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0043086 negative regulation of catalytic activity IBA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IBA
 biological_processGO:1901164 negative regulation of trophoblast cell migration ISO
 biological_processGO:1905049 negative regulation of metallopeptidase activity ISO
 biological_processGO:2001044 regulation of integrin-mediated signaling pathway ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005615 extracellular space ISS
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IBA
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd,Tg(Pdx1-cre)1Heed/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Timp1tm1Pds/Timp1tm1Pds
Genetic Background: involves: C57BL/6

Allelic Composition: Mmp7tm1Lmm/Mmp7tm1Lmm,Timp1tm1Pds/Timp1tm1Pds
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mmp3tm1Mrl/Mmp3tm1Mrl,Timp1tm1Pds/Timp1tm1Pds
Genetic Background: involves: C57BL/6

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Timp1tm1Pds/Timp1tm1Pds
Genetic Background: either: (involves: 129S4/SvJae) or (involves: C57BL/6)

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Timp1tm1Pds/Timp1tm1Pds
Genetic Background: either: (involves: 129S4/SvJae) or (involves: C57BL/6)

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Timp1tm1Pds/Y
Genetic Background: involves: 129S4/SvJae

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0009014 prolonged proestrus "increase in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0009016 abnormal estrus "any anomaly or aberrant timing of the phase of the estrous cycle which begins with the ovulation of fully mature oocytes and during which the vulva remains in an extended state with an open vagina, and females are maximally receptive to male advances" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0009018 short estrus "decrease in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0009021 absent estrus "absence or failure of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013400 abnormal endometrial gland development "aberrant formation or incomplete differentiation of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna, PMID:23619340]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017737 Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*  / reaction / complex






 

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