ENSMUSG00000017466


Mus musculus

Features
Gene ID: ENSMUSG00000017466
  
Biological name :Timp2
  
Synonyms : Timp2 / tissue inhibitor of metalloproteinase 2
  
Possible biological names infered from orthology : P16035 / TIMP metallopeptidase inhibitor 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 118301069
Gene end: 118355740
  
Corresponding Affymetrix probe sets: 10393559 (MoGene1.0st)   1420924_at (Mouse Genome 430 2.0 Array)   1433662_s_at (Mouse Genome 430 2.0 Array)   1437081_at (Mouse Genome 430 2.0 Array)   1450040_at (Mouse Genome 430 2.0 Array)   1454677_at (Mouse Genome 430 2.0 Array)   1460287_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122642
Ensembl peptide - ENSMUSP00000017610
NCBI entrez gene - 21858     See in Manteia.
MGI - MGI:98753
RefSeq - NM_011594
RefSeq Peptide - NP_035724
swissprot - B1AQJ3
swissprot - Q6PI17
Ensembl - ENSMUSG00000017466
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timp2aENSDARG00000061226Danio rerio
 timp2bENSDARG00000075261Danio rerio
 TIMP2ENSGALG00000027070Gallus gallus
 TIMP2ENSG00000035862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Timp4 / Q9JHB3 / tissue inhibitor of metalloproteinase 4 / Q99727* / TIMP metallopeptidase inhibitor 4*ENSMUSG0000003031742
Timp3 / P39876 / tissue inhibitor of metalloproteinase 3 / P35625* / TIMP metallopeptidase inhibitor 3*ENSMUSG0000002004439
Timp1 / P12032 / Metalloproteinase inhibitor 1 / P01033* / TIMP metallopeptidase inhibitor 1*ENSMUSG0000000113119


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015613  Metalloproteinase inhibitor 2
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0032487 regulation of Rap protein signal transduction IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045762 positive regulation of adenylate cyclase activity IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:1905049 negative regulation of metallopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / complex / reaction
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr