Manteia - Molecule gene

ENSMUSG00000020044

Mus musculus

Features

Gene ID:	ENSMUSG00000020044

Biological name :	Timp3

Synonyms :	P39876 / Timp3 / tissue inhibitor of metalloproteinase 3

Possible biological names infered from orthology :	P35625 / TIMP metallopeptidase inhibitor 3

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	C1
Gene start:	86300372
Gene end:	86349506

Corresponding Affymetrix probe sets:	10365482 (MoGene1.0st) 1419088_at (Mouse Genome 430 2.0 Array) 1419089_at (Mouse Genome 430 2.0 Array) 1449334_at (Mouse Genome 430 2.0 Array) 1449335_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000133236 Ensembl peptide - ENSMUSP00000020234 NCBI entrez gene - 21859 See in Manteia. MGI - MGI:98754 RefSeq - NM_011595 RefSeq Peptide - NP_035725 swissprot - E9QAB2 swissprot - P39876 swissprot - Q54AE5 Ensembl - ENSMUSG00000020044

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
TIMP3	ENSGALG00000028627	Gallus gallus
TIMP3	ENSG00000100234	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Timp4 / Q9JHB3 / tissue inhibitor of metalloproteinase 4 / Q99727* / TIMP metallopeptidase inhibitor 4*	ENSMUSG00000030317	43
Timp2 / tissue inhibitor of metalloproteinase 2 / P16035* / TIMP metallopeptidase inhibitor 2*	ENSMUSG00000017466	40
Timp1 / P12032 / Metalloproteinase inhibitor 1 / P01033* / TIMP metallopeptidase inhibitor 1*	ENSMUSG00000001131	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR001134	Netrin domain
IPR001820	Protease inhibitor I35 (TIMP)
IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
IPR015612	Metalloproteinase inhibitor 3
IPR027465	Proteinase inhibitor I35b (TIMP), C-terminal
IPR030490	Tissue inhibitor of metalloproteinase, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0010466	negative regulation of peptidase activity	IEA
biological_process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	IEA
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IEA
biological_process	GO:0071310	cellular response to organic substance	IDA
biological_process	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	IEA
biological_process	GO:1904684	negative regulation of metalloendopeptidase activity	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005604	basement membrane	IDA
cellular_component	GO:0005615	extracellular space	IDA
cellular_component	GO:0031012	extracellular matrix	IEA
molecular_function	GO:0002020	protease binding	IBA
molecular_function	GO:0004857	enzyme inhibitor activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	IEA
molecular_function	GO:0008270	zinc ion binding	ISS
molecular_function	GO:0030414	peptidase inhibitor activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Platelet degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bdnf^tm1Par/Bdnf⁺ Genetic Background: B6.129S1-Bdnf^tm1Par
MP:0000230	abnormal blood pressure	"altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0000249	abnormal blood vessel physiology	"anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya
MP:0000420	ruffled hair	"fuzzy, irregular appearance of the hair" [J:50844]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya
MP:0001183	overexpanded alveoli	"expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0001648	abnormal apoptosis	"excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001654	hepatic necrosis	"pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0001882	abnormal lactation	"atypical production of milk from the mammary gland" [J:51296]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002063	abnormal learning/memory/conditioning	"altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002133	abnormal respiratory system physiology	"anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0002191	abnormal artery morphology	"malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0002267	abnormal bronchiole morphology	"any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002608	increased hematocrit	"greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho,Tnf^tm1Gkl/Tnf^tm1Gkl Genetic Background: involves: 129 * 129S/SvEv * C57BL/6
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0002843	decreased blood pressure	"decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0003068	enlarged kidney	"larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003227	abnormal vascular branching morphogenesis	"increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]	Show Allelic Composition: Myo5a^rgsc235/Myo5a^rgsc235 Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0003822	decreased left ventricle systolic pressure	"decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0003824	decreased left ventricular developed pressure	"decrease in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0003828	pulmonary edema	"an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0004084	abnormal cardiac muscle relaxation	"altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0004485	increased response of heart to induced stress	"increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005165	increased susceptibility to injury	"greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya
MP:0005201	abnormal retinal pigment epithelium morphology	"anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dbm4^C57BL/6J/?,Ins2^Akita/Ins2⁺ Genetic Background: involves: A/J * C57BL/6J * C57BL/6NSlc Allelic Composition: Timp3^tm1Web/Timp3^tm1Web Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005239	abnormal Bruch membrane morphology	"anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dbm4^C57BL/6J/?,Ins2^Akita/Ins2⁺ Genetic Background: involves: A/J * C57BL/6J * C57BL/6NSlc Allelic Composition: Timp3^tm1Web/Timp3^tm1Web Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0005517	decreased liver regeneration	"less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0005533	increased body temperature	"greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0005591	decreased vasodilation	"less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho,Tnf^tm1Gkl/Tnf^tm1Gkl Genetic Background: involves: 129 * 129S/SvEv * C57BL/6
MP:0006026	dilated terminal bronchiole tubes	"increased volume of the terminal lung buds" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0006027	impaired alveologenesis	"a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0006083	abnormal vascular elastic tissue	"malformation in the tissue that is found in the tunica media of the vessels wall and allows vessels to stretch" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Omg^tm1.3Bzh/Omg^tm1.3Bzh Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N * SJL
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006237	abnormal choroid vasculature	"malformation of the blood vessels of the choroid" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Myo5a^rgsc235/Myo5a^rgsc235 Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0006271	abnormal involution of the mammary gland	"anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0008963	increased carbon dioxide production	"increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0008987	abnormal liver lobule morphology	"any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc6a3^tm1Mca/Slc6a3^tm1Mca Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0009866	abnormal aorta wall morphology	"any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009870	abnormal abdominal aorta morphology	"any structural anomaly of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, and supplies oxygenated blood to all of the abdominal and pelvic organs and the legs" [http://www.medterms.com "MedicineNet.com"]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Syt1^{tm1a(EUCOMM)Wtsi}/Syt1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Syt1^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010139	aortitis	"inflammation of the aorta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010659	abdominal aorta aneurysm	"a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: B6.129P2-Timp3^tm1Osya Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Timp3^tm1Osya/Timp3^tm1Osya Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010903	abnormal pulmonary alveolus wall morphology		Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0011031	abnormal branching involved in terminal bronchiole morphogenesis	"anomaly in the process in which the branched structure of the terminal bronchioles are generated and organized" [MGI:csmith]	Show Allelic Composition: Timp3^tm1Rkho/Timp3^tm1Rkho Genetic Background: B6.129-Timp3^tm1Rkho
MP:0020523	decreased susceptibility to induced hypothermia	"smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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