ENSGALG00000028627


Gallus gallus

Features
Gene ID: ENSGALG00000028627
  
Biological name :TIMP3
  
Synonyms : Metalloproteinase inhibitor 3 / P26652 / TIMP3
  
Possible biological names infered from orthology : P35625 / P39876 / TIMP metallopeptidase inhibitor 3 / tissue inhibitor of metalloproteinase 3
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 53145365
Gene end: 53177923
  
Corresponding Affymetrix probe sets: Gga.2827.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000040866
NCBI entrez gene - 396483     See in Manteia.
RefSeq - NM_205487
RefSeq Peptide - NP_990818
swissprot - P26652
swissprot - R4GFR4
Ensembl - ENSGALG00000028627
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIMP3ENSG00000100234Homo sapiens
 Timp3ENSMUSG00000020044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIMP4 / TIMP metallopeptidase inhibitor 4 / Q99727* / Q9JHB3* / tissue inhibitor of metalloproteinase 4*ENSGALG0000000496950
TIMP2 / metalloproteinase inhibitor 2 precursor / P16035* / TIMP metallopeptidase inhibitor 2* / tissue inhibitor of metalloproteinase 2*ENSGALG0000002707044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015612  Metalloproteinase inhibitor 3
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010033 response to organic substance IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0043086 negative regulation of catalytic activity IBA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway IEA
 biological_processGO:1904684 negative regulation of metalloendopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IBA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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