ENSGALG00000027070


Gallus gallus

Features
Gene ID: ENSGALG00000027070
  
Biological name :TIMP2
  
Synonyms : metalloproteinase inhibitor 2 precursor / TIMP2
  
Possible biological names infered from orthology : P16035 / TIMP metallopeptidase inhibitor 2 / tissue inhibitor of metalloproteinase 2
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 9854402
Gene end: 9861353
  
Corresponding Affymetrix probe sets: Gga.2965.1.S1_at (Chicken Array)   Gga.2965.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000041954
NCBI entrez gene - 374178     See in Manteia.
RefSeq - NM_204298
RefSeq Peptide - NP_989629
swissprot - R4GIL5
Ensembl - ENSGALG00000027070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timp2aENSDARG00000061226Danio rerio
 timp2bENSDARG00000075261Danio rerio
 TIMP2ENSG00000035862Homo sapiens
 Timp2ENSMUSG00000017466Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIMP4 / TIMP metallopeptidase inhibitor 4 / Q99727* / Q9JHB3* / tissue inhibitor of metalloproteinase 4*ENSGALG0000000496949
TIMP3 / P26652 / Metalloproteinase inhibitor 3 / P39876* / P35625* / TIMP metallopeptidase inhibitor 3* / tissue inhibitor of metalloproteinase 3*ENSGALG0000002862743


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015613  Metalloproteinase inhibitor 2
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:1905049 negative regulation of metallopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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