ENSDARG00000061226


Danio rerio

Features
Gene ID: ENSDARG00000061226
  
Biological name :timp2a
  
Synonyms : timp2a / TIMP metallopeptidase inhibitor 2a
  
Possible biological names infered from orthology : P16035 / TIMP2 / TIMP metallopeptidase inhibitor 2 / tissue inhibitor of metalloproteinase 2
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 33990947
Gene end: 34035364
  
Corresponding Affymetrix probe sets: Dr.240.1.A1_at (Zebrafish Array)   NM_182874_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000081499
NCBI entrez gene - 359835     See in Manteia.
RefSeq - NM_182874
RefSeq Peptide - NP_878294
swissprot - Q1RLX2
ZFIN ID - ZDB-GENE-030612-1
Ensembl - ENSDARG00000061226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIMP2ENSGALG00000027070Gallus gallus
 TIMP2ENSG00000035862Homo sapiens
 Timp2ENSMUSG00000017466Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
timp2b / TIMP metallopeptidase inhibitor 2b / TIMP2* / P16035* / TIMP metallopeptidase inhibitor 2*ENSDARG0000007526161
timp4.1 / TIMP metallopeptidase inhibitor 4, tandem duplicate 1 / TIMP4* / Q99727* / TIMP metallopeptidase inhibitor 4*ENSDARG0000011180527
timp4.2 / TIMP metallopeptidase inhibitor 4, tandem duplicate 2ENSDARG0000010261719
timp4.3 / TIMP metallopeptidase inhibitor 4, tandem duplicate 3ENSDARG0000010079518


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015613  Metalloproteinase inhibitor 2
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009725 response to hormone IBA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0043086 negative regulation of catalytic activity IBA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism morphology , abnormal
whole organism decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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