ENSMUSG00000030317


Mus musculus

Features
Gene ID: ENSMUSG00000030317
  
Biological name :Timp4
  
Synonyms : Q9JHB3 / Timp4 / tissue inhibitor of metalloproteinase 4
  
Possible biological names infered from orthology : Q99727 / TIMP metallopeptidase inhibitor 4
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E3
Gene start: 115241892
Gene end: 115252205
  
Corresponding Affymetrix probe sets: 10547022 (MoGene1.0st)   1423405_at (Mouse Genome 430 2.0 Array)   1435833_at (Mouse Genome 430 2.0 Array)   1450974_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032462
Ensembl peptide - ENSMUSP00000144785
NCBI entrez gene - 110595     See in Manteia.
MGI - MGI:109125
RefSeq - XM_017321325
RefSeq - NM_080639
RefSeq - XM_006505367
RefSeq Peptide - NP_542370
swissprot - Q3USH7
swissprot - Q9JHB3
swissprot - A0A0N4SUR1
Ensembl - ENSMUSG00000030317
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timp4.1ENSDARG00000111805Danio rerio
 TIMP4ENSGALG00000004969Gallus gallus
 TIMP4ENSG00000157150Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Timp2 / tissue inhibitor of metalloproteinase 2 / P16035* / TIMP metallopeptidase inhibitor 2*ENSMUSG0000001746641
Timp3 / P39876 / tissue inhibitor of metalloproteinase 3 / P35625* / TIMP metallopeptidase inhibitor 3*ENSMUSG0000002004441
Timp1 / P12032 / Metalloproteinase inhibitor 1 / P01033* / TIMP metallopeptidase inhibitor 1*ENSMUSG0000000113121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015614  Metalloproteinase inhibitor 4
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0043086 negative regulation of catalytic activity IBA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0030017 sarcomere IEA
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003023 decreased coronary flow rate "reduced rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr