ENSDARG00000062909


Danio rerio

Features
Gene ID: ENSDARG00000062909
  
Biological name :furina
  
Synonyms : furina / furin (paired basic amino acid cleaving enzyme) a
  
Possible biological names infered from orthology : FURIN / furin, paired basic amino acid cleaving enzyme / P09958 / P23188
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 13988075
Gene end: 14207006
  
Corresponding Affymetrix probe sets: Dr.9045.1.A1_at (Zebrafish Array)   Dr.9045.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000152673
Ensembl peptide - ENSDARP00000085903
Ensembl peptide - ENSDARP00000146701
NCBI entrez gene - 566557     See in Manteia.
RefSeq - XM_009302953
swissprot - F1QQ43
ZFIN ID - ZDB-GENE-040901-1
Ensembl - ENSDARG00000062909
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FURINENSGALG00000008341Gallus gallus
 FURINENSG00000140564Homo sapiens
 FurinENSMUSG00000030530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000007097171
pcsk5a / proprotein convertase subtilisin/kexin type 5a / PCSK5* / Q92824* / Q04592* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006753743
pcsk1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *ENSDARG0000000260038
pcsk2 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSDARG0000001945134
pcsk5b / proprotein convertase subtilisin/kexin type 5b / PCSK5* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006051833
pcsk7 / proprotein convertase subtilisin/kexin type 7 / Q16549*ENSDARG0000006996830
pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSDARG0000010457415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0033334 fin morphogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0071907 determination of digestive tract left/right asymmetry IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Activation of Matrix Metalloproteinases
Removal of aminoterminal propeptides from gamma-carboxylated proteins
NGF processing
Signaling by PDGF
Pre-NOTCH Processing in Golgi
TGF-beta receptor signaling activates SMADs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic process increased occurrence , abnormal
brain cell proliferation decreased occurrence , abnormal
Show

 ZFA:0000040 median fin fold median fin fold blistered , abnormal
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 ZFA:0000076 swim bladder swim bladder aplastic , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000100 cerebellum cerebellum degenerate , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000112 gut gut position , abnormal
Show

 ZFA:0000114 heart heart position , abnormal
heart morphology , abnormal
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 ZFA:0000123 liver liver position , abnormal
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 ZFA:0000250 opercle opercle shape , abnormal
opercle increased size , abnormal
opercle size , abnormal
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 ZFA:0000360 heart tube heart tube morphology , abnormal
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 ZFA:0000445 optic tectum optic tectum degenerate , abnormal
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 ZFA:0000476 branchiostegal ray branchiostegal ray position , abnormal
branchiostegal ray malformed , abnormal
branchiostegal ray falciform , abnormal
branchiostegal ray decreased size , abnormal
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 ZFA:0000547 mouth mouth open , abnormal
mouth concave 3-D shape , abnormal
mouth quality , abnormal
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 ZFA:0000692 symplectic symplectic increased length , abnormal
symplectic in contact with Meckels cartilage , abnormal
Show

 ZFA:0000737 cranium cranium has extra parts of type cranial cartilage , abnormal
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 ZFA:0001058 caudal fin caudal fin ruffled , abnormal
caudal fin morphology , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism decreased life span , abnormal
whole organism anterior-posterior axis decreased length , abnormal
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 ZFA:0001114 head head anterior region truncated , abnormal
head decreased size , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage fused with palatoquadrate cartilage , abnormal
Meckels cartilage decreased size , abnormal
Meckels cartilage mislocalised posteriorly , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium quality , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton joint absent , abnormal
mandibular arch skeleton hypoplastic , abnormal
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 ZFA:0001228 pharyngeal arch 3 skeleton pharyngeal arch 3 skeleton decreased size , abnormal
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 ZFA:0001231 pharyngeal arch 4 skeleton pharyngeal arch 4 skeleton decreased size , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch quality , abnormal
ventral mandibular arch decreased size , abnormal
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 ZFA:0001280 branchiostegal ray 3 branchiostegal ray 3 shape , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch joint absent , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage increased length , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage fused with hyosymplectic cartilage , abnormal
ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage inverted , abnormal
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 ZFA:0001402 ventral hyoid arch ventral hyoid arch morphology , abnormal
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 ZFA:0001510 basihyal cartilage basihyal cartilage shape , abnormal
basihyal cartilage hyperplastic , abnormal
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 ZFA:0005465 ceratohyal-branchiostegal ray joint ceratohyal-branchiostegal ray joint morphology , abnormal
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 ZFA:0005473 interhyal-epihyal joint interhyal-epihyal joint absent , abnormal
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 ZFA:0009048 granulocyte granulocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / reaction
 ENSDARG00000058876 mmp16b / matrix metallopeptidase 16b (membrane-inserted) / MMP16* / P51512* / Q9WTR0* / matrix metallopeptidase 16* / Matrix metalloproteinase-16 *  / reaction
 ENSDARG00000010097 f9a / coagulation factor IXa / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*  / reaction
 ENSDARG00000029493 f9b / coagulation factor IXb / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*  / reaction
 ENSDARG00000100782 zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*  / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / reaction
 ENSDARG00000008388 mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *  / reaction
 ENSDARG00000037783 proza / protein Z, vitamin K-dependent plasma glycoprotein a / PROZ* / P22891* / protein Z, vitamin K dependent plasma glycoprotein*  / reaction
 ENSDARG00000034895 tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*  / reaction
 ENSDARG00000076900 prozb / protein Z, vitamin K-dependent plasma glycoprotein b / PROZ* / P22891* / Q9CQW3* / protein Z, vitamin K dependent plasma glycoprotein*  / reaction
 ENSDARG00000088581 f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*  / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction
 ENSDARG00000026325 mmp11a / matrix metallopeptidase 11a / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*  / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction






 

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