ENSDARG00000038139


Danio rerio

Features
Gene ID: ENSDARG00000038139
  
Biological name :pdgfbb
  
Synonyms : pdgfbb / platelet-derived growth factor beta polypeptide b
  
Possible biological names infered from orthology : P01127 / PDGFB / platelet derived growth factor, B polypeptide / platelet derived growth factor subunit B
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 24275597
Gene end: 24297419
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000055606
Ensembl peptide - ENSDARP00000130601
Ensembl peptide - ENSDARP00000146623
NCBI entrez gene - 796490     See in Manteia.
swissprot - E7FBB3
ZFIN ID - ZDB-GENE-131121-332
Ensembl - ENSDARG00000038139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDGFBENSGALG00000012178Gallus gallus
 PDGFBENSG00000100311Homo sapiens
 PdgfbENSMUSG00000000489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*ENSDARG0000008677823
pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*ENSDARG000001093711
pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*ENSDARG000001100691
pdgfab / platelet-derived growth factor alpha polypeptide b / PDGFA* / P04085* / platelet derived growth factor subunit A*ENSDARG000000985781


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR015583  Platelet-derived growth factor subunit B
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003347 epicardial cell to mesenchymal cell transition IDA
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IBA
 biological_processGO:0035791 platelet-derived growth factor receptor-beta signaling pathway IMP
 biological_processGO:0042246 tissue regeneration IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IBA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:1903392 negative regulation of adherens junction organization IDA
 biological_processGO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028699 crkl / v-crk avian sarcoma virus CT10 oncogene homolog-like / P46109* / P47941* / Crk-like protein * / CRK like proto-oncogene, adaptor protein*  / reaction / complex
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000035535 rasa1a / RAS p21 protein activator (GTPase activating protein) 1a / RASA1* / P20936* / RAS p21 protein activator 1*  / complex / reaction
 ENSDARG00000073810 thbs2b / thrombospondin 2b / THBS2* / Q03350* / P35442* / thrombospondin 2*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000073665 rasa1b / RAS p21 protein activator (GTPase activating protein) 1b / RASA1* / P20936* / RAS p21 protein activator 1*  / complex / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / reaction / complex
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000102777 thbs4a / thrombospondin 4a / THBS4* / P35443* / thrombospondin 4*  / reaction / complex
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000012060 Q1L8P7 / thbs3b / thrombospondin 3b / THBS3* / Q05895* / P49746* / thrombospondin 3*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction / complex
 ENSDARG00000010785 thbs1b / thrombospondin 1b / THBS1* / P07996* / thrombospondin 1*  / complex / reaction
 ENSDARG00000060410 thbs2a / thrombospondin 2a / THBS2* / Q03350* / P35442* / thrombospondin 2*  / reaction / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / reaction / complex
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr