ENSGALG00000012178


Gallus gallus

Features
Gene ID: ENSGALG00000012178
  
Biological name :PDGFB
  
Synonyms : PDGFB / platelet derived growth factor subunit B
  
Possible biological names infered from orthology : P01127 / platelet derived growth factor, B polypeptide
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 50759960
Gene end: 50771537
  
Corresponding Affymetrix probe sets: Gga.71.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019858
NCBI entrez gene - 374128     See in Manteia.
RefSeq - XM_015284377
RefSeq - NM_204270
RefSeq - XM_015284369
RefSeq - XM_015284373
RefSeq Peptide - NP_989601
swissprot - F1NE37
Ensembl - ENSGALG00000012178
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfbaENSDARG00000086778Danio rerio
 pdgfbbENSDARG00000038139Danio rerio
 PDGFBENSG00000100311Homo sapiens
 PdgfbENSMUSG00000000489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDGFA / platelet derived growth factor subunit A / P04085*ENSGALG0000000364232


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR006782  Platelet-derived growth factor, N-terminal
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010512 negative regulation of phosphatidylinositol biosynthetic process IEA
 biological_processGO:0010544 negative regulation of platelet activation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0035655 interleukin-18-mediated signaling pathway IEA
 biological_processGO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0072126 positive regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:1900127 positive regulation of hyaluronan biosynthetic process IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1905064 negative regulation of vascular smooth muscle cell differentiation IEA
 biological_processGO:1905176 positive regulation of vascular smooth muscle cell dedifferentiation IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 biological_processGO:2000591 positive regulation of metanephric mesenchymal cell migration IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IEA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048407 platelet-derived growth factor binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / reaction / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000008341 FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*  / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / reaction / complex
 ENSGALG00000013929 PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*  / complex
 ENSGALG00000003642 PDGFA / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSGALG00000011200 THBS2 / thrombospondin-2 precursor / P35442* / Q03350* / thrombospondin 2*  / complex / reaction
 ENSGALG00000014804 THBS4 / Gallus gallus thrombospondin 4 (THBS4), mRNA. / P35443* / Q9Z1T2* / thrombospondin 4*  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000017706 RASA1* / P20936* / RAS p21 protein activator 1*  / reaction / complex
 ENSGALG00000006390 CRKL / CRK like proto-oncogene, adaptor protein / P46109* / P47941* / Crk-like protein *  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000030613 PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *  / complex
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / reaction / complex
 ENSGALG00000042569 P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*  / reaction






 

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