ENSGALG00000003428


Gallus gallus

Features
Gene ID: ENSGALG00000003428
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : AC007192.1 / O00459 / O08908 / Phosphatidylinositol 3-kinase regulatory subunit beta / phosphoinositide-3-kinase regulatory subunit 2 / PIK3R2
  
Species: Gallus gallus
  
Chr. number: 28
Strand: -1
Band:
Gene start: 4018519
Gene end: 4028659
  
Corresponding Affymetrix probe sets: Gga.5556.2.S1_a_at (Chicken Array)   Gga.5556.3.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005414
NCBI entrez gene - 771142     See in Manteia.
RefSeq - XM_001233340
swissprot - E1C2C5
Ensembl - ENSGALG00000003428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r2ENSDARG00000018060Danio rerio
 AC007192.1ENSG00000268173Homo sapiens
 O00459ENSG00000105647Homo sapiens
 O08908ENSMUSG00000031834Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*ENSGALG0000001478646
Q64143* / PIK3R3* / Q92569* / AL358075.4* / AL670603.1* / phosphoinositide-3-kinase regulatory subunit 3* / Phosphatidylinositol 3-kinase regulatory subunit gamma *ENSGALG0000001033543


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR001720  PI3K p85/p55 subunit
 IPR008936  Rho GTPase activation protein
 IPR032498  PI3K p85 subunit, inter-SH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IBA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IEA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
Rho GTPase cycle
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001840 TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*  / complex / reaction
 ENSGALG00000002583 PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*  / complex
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / reaction / complex
 ENSGALG00000030613 PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *  / reaction / complex
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction / complex
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / reaction / complex
 ENSGALG00000013929 PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*  / reaction / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / reaction / complex
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000003642 PDGFA / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSGALG00000023781 TREM2 / triggering receptor expressed on myeloid cells 2 / Q99NH8* / Q9NZC2*  / reaction / complex
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000029983 ANGPT1 / angiopoietin 1 / O08538* / Q15389*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex






 

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