ENSGALG00000013907


Gallus gallus

Features
Gene ID: ENSGALG00000013907
  
Biological name :KDR
  
Synonyms : KDR / vascular endothelial growth factor receptor 2 precursor
  
Possible biological names infered from orthology : kinase insert domain receptor / P35968
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 65598124
Gene end: 65625791
  
Corresponding Affymetrix probe sets: Gga.7339.1.S1_at (Chicken Array)   Gga.807.1.S1_at (Chicken Array)   Gga.807.1.S1_x_at (Chicken Array)   Gga.953.1.S1_at (Chicken Array)   GgaAffx.8835.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000022522
NCBI entrez gene - 395323     See in Manteia.
RefSeq - NM_001004368
RefSeq Peptide - NP_001004368
swissprot - F1NW21
Ensembl - ENSGALG00000013907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdrENSDARG00000017321Danio rerio
 KDRENSG00000128052Homo sapiens
 KdrENSMUSG00000062960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLT4 / fms related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSGALG0000000580246
FLT1 / vascular endothelial growth factor receptor 1 precursor / P17948* / fms related tyrosine kinase 1*ENSGALG0000001709143
ENSGALG0000000764642
PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*ENSGALG0000001392923
CSF1R / Gallus gallus colony stimulating factor 1 receptor (CSF1R), mRNA. / P07333* / P09581* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSGALG0000000572522
PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *ENSGALG0000003061322
KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSGALG0000003863420
FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*ENSGALG0000003978619
FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*ENSGALG0000001570819
FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSGALG0000000949519
FLT3 / fms related tyrosine kinase 3 / P36888*ENSGALG0000003572618
FGFR4 / fibroblast growth factor receptor 4 / P22455*ENSGALG0000002854318
RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*ENSGALG0000000255517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009136  Vascular endothelial growth factor receptor 2 (VEGFR2)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000001289 SHC2 / SHC adaptor protein 2 / P98077* / Q8BMC3* / SHC (Src homology 2 domain containing) transforming protein 2*  / complex / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / complex / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / reaction / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / reaction / complex
 ENSGALG00000035492 ELMO1 / engulfment and cell motility 1 / Q8BPU7* / Q92556* / Engulfment and cell motility protein 1 *  / reaction / complex
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSGALG00000042259 DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *  / reaction / complex
 ENSGALG00000016451 ROCK2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction
 ENSGALG00000016564 PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*  / reaction / complex
 ENSGALG00000014922 ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *  / reaction
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr