ENSGALG00000001289


Gallus gallus

Features
Gene ID: ENSGALG00000001289
  
Biological name :SHC2
  
Synonyms : SHC2 / SHC adaptor protein 2
  
Possible biological names infered from orthology : P98077 / Q8BMC3 / SHC (Src homology 2 domain containing) transforming protein 2
  
Species: Gallus gallus
  
Chr. number: 28
Strand: -1
Band:
Gene start: 2657406
Gene end: 2666166
  
Corresponding Affymetrix probe sets: GgaAffx.863.2.S1_at (Chicken Array)   GgaAffx.863.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047656
Ensembl peptide - ENSGALP00000001966
NCBI entrez gene - 770341     See in Manteia.
RefSeq - XM_015300006
RefSeq - XM_001233681
RefSeq - XM_015300005
swissprot - F1NYE2
swissprot - A0A1D5P4P4
Ensembl - ENSGALG00000001289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shc2ENSDARG00000062080Danio rerio
 SHC2ENSG00000129946Homo sapiens
 Shc2ENSMUSG00000020312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHC3 / SHC adaptor protein 3 / Q61120* / Q92529* / src homology 2 domain-containing transforming protein C3*ENSGALG0000001068848
SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *ENSGALG0000003977548
SHC4* / Q6S5L8* / Q6S5L9* / SHC adaptor protein 4* / SHC (Src homology 2 domain containing) family, member 4*ENSGALG000000050118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029591  SHC-transforming protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA


Pathways (from Reactome)
Pathway description
Signalling to RAS
VEGFA-VEGFR2 Pathway
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction






 

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