Manteia - Molecule gene

ENSMUSG00000020312

Mus musculus

Features

Gene ID:	ENSMUSG00000020312

Biological name :	Shc2

Synonyms :	Q8BMC3 / Shc2 / SHC (Src homology 2 domain containing) transforming protein 2

Possible biological names infered from orthology :	P98077 / SHC adaptor protein 2

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	C1
Gene start:	79618051
Gene end:	79637918

Corresponding Affymetrix probe sets:	10370587 (MoGene1.0st) 1437944_at (Mouse Genome 430 2.0 Array) 1438598_at (Mouse Genome 430 2.0 Array) 1441356_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020564 NCBI entrez gene - 216148 See in Manteia. MGI - MGI:106180 RefSeq - NM_001024539 RefSeq Peptide - NP_001019710 swissprot - E9QLZ0 swissprot - Q8BMC3 Ensembl - ENSMUSG00000020312

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
shc2	ENSDARG00000062080	Danio rerio
SHC2	ENSGALG00000001289	Gallus gallus
SHC2	ENSG00000129946	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*	ENSMUSG00000042626	48
Shc3 / Q61120 / src homology 2 domain-containing transforming protein C3 / Q92529* / SHC adaptor protein 3*	ENSMUSG00000021448	45
Shc4 / Q6S5L9 / SHC (Src homology 2 domain containing) family, member 4 / Q6S5L8* / SHC adaptor protein 4*	ENSMUSG00000035109	41

Protein motifs (from Interpro)

Interpro ID	Name
IPR000980	SH2 domain
IPR006019	Phosphotyrosine interaction domain, Shc-like
IPR006020	PTB/PI domain
IPR011993	PH-like domain superfamily
IPR029591	SHC-transforming protein 2
IPR035676	SH2 adaptor protein C, SH2 domain
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000187	activation of MAPK activity	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA
biological_process	GO:0035556	intracellular signal transduction	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005886	plasma membrane	IBA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0030971	receptor tyrosine kinase binding	IBA

Pathways (from Reactome)

Pathway description

Signalling to RAS

VEGFA-VEGFR2 Pathway

RAF/MAP kinase cascade

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Sox3^tm1Rlb/Y Genetic Background: involves: 129S7/SvEvBrd * MF1 Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000964	small dorsal root ganglia	"reduced size of the dorsal root ganglia" [J:17123]	Show Allelic Composition: Sox3^tm1Rlb/Y Genetic Background: involves: 129S7/SvEvBrd * MF1 Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000965	abnormal sensory neuron morphology	"malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Sox3^tm1Rlb/Y Genetic Background: involves: 129S7/SvEvBrd * MF1 Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0000969	abnormal nociceptor morphology	"anomalous structure of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sox3^tm1Rlb/Y Genetic Background: involves: 129S7/SvEvBrd * MF1 Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv
MP:0001015	small superior cervical ganglion	"reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]	Show Allelic Composition: Shc2^tm1Paw/Shc2^tm1Paw,Shc3^tm1Paw/Shc3^tm1Paw Genetic Background: involves: 129/Sv

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000023951	Vegfa / Q00731 / vascular endothelial growth factor A / P15692*	/ reaction / complex
ENSMUSG00000062960	Kdr / kinase insert domain receptor / P35968*	/ complex / reaction
ENSMUSG00000024241	Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*	/ reaction / complex
ENSMUSG00000059923	Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr