ENSG00000129946


Homo sapiens

Features
Gene ID: ENSG00000129946
  
Biological name :SHC2
  
Synonyms : P98077 / SHC2 / SHC adaptor protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 416583
Gene end: 460996
  
Corresponding Affymetrix probe sets: 213464_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264554
Ensembl peptide - ENSP00000465764
Ensembl peptide - ENSP00000466869
NCBI entrez gene - 25759     See in Manteia.
OMIM - 605217
RefSeq - XM_017026567
RefSeq - XM_011527893
RefSeq - XM_011527894
RefSeq - XM_011527895
RefSeq - XM_011527896
RefSeq - NM_012435
RefSeq Peptide - NP_036567
swissprot - K7ENB2
swissprot - K7EKS8
swissprot - P98077
Ensembl - ENSG00000129946
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shc2ENSDARG00000062080Danio rerio
 SHC2ENSGALG00000001289Gallus gallus
 Shc2ENSMUSG00000020312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHC1 / P29353 / SHC adaptor protein 1ENSG0000016069148
SHC3 / Q92529 / SHC adaptor protein 3ENSG0000014808246
SHC4 / Q6S5L8 / SHC adaptor protein 4ENSG0000018563440


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029591  SHC-transforming protein 2
 IPR035676  SH2 adaptor protein C, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Signalling to RAS
VEGFA-VEGFR2 Pathway
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr