ENSG00000112715


Homo sapiens

Features
Gene ID: ENSG00000112715
  
Biological name :VEGFA
  
Synonyms : P15692 / vascular endothelial growth factor A / VEGFA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 43770184
Gene end: 43786487
  
Corresponding Affymetrix probe sets: 210512_s_at (Human Genome U133 Plus 2.0 Array)   210513_s_at (Human Genome U133 Plus 2.0 Array)   211527_x_at (Human Genome U133 Plus 2.0 Array)   212171_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428321
Ensembl peptide - ENSP00000421561
Ensembl peptide - ENSP00000429008
Ensembl peptide - ENSP00000492800
Ensembl peptide - ENSP00000492413
Ensembl peptide - ENSP00000492199
Ensembl peptide - ENSP00000484284
Ensembl peptide - ENSP00000483241
Ensembl peptide - ENSP00000478570
Ensembl peptide - ENSP00000478034
Ensembl peptide - ENSP00000430829
Ensembl peptide - ENSP00000430594
Ensembl peptide - ENSP00000430479
Ensembl peptide - ENSP00000430002
Ensembl peptide - ENSP00000429643
Ensembl peptide - ENSP00000429592
Ensembl peptide - ENSP00000230480
Ensembl peptide - ENSP00000317598
Ensembl peptide - ENSP00000361125
Ensembl peptide - ENSP00000361134
Ensembl peptide - ENSP00000361137
Ensembl peptide - ENSP00000361148
Ensembl peptide - ENSP00000388465
Ensembl peptide - ENSP00000388663
Ensembl peptide - ENSP00000389864
Ensembl peptide - ENSP00000409911
NCBI entrez gene - 7422     See in Manteia.
OMIM - 192240
RefSeq - NM_001171623
RefSeq - NM_001025366
RefSeq - NM_001025367
RefSeq - NM_001025368
RefSeq - NM_001025369
RefSeq - NM_001025370
RefSeq - NM_001033756
RefSeq - NM_001171622
RefSeq - NM_001171624
RefSeq - NM_001171625
RefSeq - NM_001171626
RefSeq - NM_001171627
RefSeq - NM_001171628
RefSeq - NM_001171629
RefSeq - NM_001171630
RefSeq - NM_001204384
RefSeq - NM_001204385
RefSeq - NM_001287044
RefSeq - NM_001317010
RefSeq - NM_003376
RefSeq Peptide - NP_001020540
RefSeq Peptide - NP_001028928
RefSeq Peptide - NP_001165093
RefSeq Peptide - NP_001165094
RefSeq Peptide - NP_001165095
RefSeq Peptide - NP_001165096
RefSeq Peptide - NP_001165097
RefSeq Peptide - NP_001165098
RefSeq Peptide - NP_001165099
RefSeq Peptide - NP_001165100
RefSeq Peptide - NP_001165101
RefSeq Peptide - NP_001191313
RefSeq Peptide - NP_001191314
RefSeq Peptide - NP_001273973
RefSeq Peptide - NP_001303939
RefSeq Peptide - NP_003367
RefSeq Peptide - NP_001020537
RefSeq Peptide - NP_001020538
RefSeq Peptide - NP_001020539
RefSeq Peptide - NP_001020541
swissprot - A2A2V4
swissprot - A0A0Y0IMM4
swissprot - A0A0A0MTB2
swissprot - A0A0A0MSI7
swissprot - A0A024RD33
swissprot - A0A0A0MSH7
swissprot - A0A0A0MSH5
swissprot - A0A0A0MRQ4
swissprot - A0A0A0MR43
swissprot - A0A087X1L1
swissprot - A0A087X0B2
swissprot - A0A087WUD8
swissprot - A0A087WTP4
swissprot - A0A024RD37
swissprot - H0YBI8
swissprot - H0YBZ0
swissprot - P15692
swissprot - H3BLW8
swissprot - J3KPA4
Ensembl - ENSG00000112715
  
Related genetic diseases (OMIM): 603933 - {Microvascular complications of diabetes 1}, 603933
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O73682ENSDARG00000103542Danio rerio
 vegfabENSDARG00000034700Danio rerio
 VEGFAENSGALG00000010290Gallus gallus
 VegfaENSMUSG00000023951Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PGF / P49763 / placental growth factorENSG0000011963017
VEGFB / P49765 / vascular endothelial growth factor BENSG0000017351113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR027928  Vascular endothelial growth factor, heparin-binding domain
 IPR029034  Cystine-knot cytokine
 IPR036841  Vascular endothelial growth factor, heparin-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001541 ovarian follicle development ISS
 biological_processGO:0001569 branching involved in blood vessel morphogenesis ISS
 biological_processGO:0001570 vasculogenesis TAS
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0001701 in utero embryonic development ISS
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISS
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0002052 positive regulation of neuroblast proliferation ISS
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation ISS
 biological_processGO:0002092 positive regulation of receptor internalization IDA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0002687 positive regulation of leukocyte migration TAS
 biological_processGO:0003007 heart morphogenesis ISS
 biological_processGO:0003151 outflow tract morphogenesis ISS
 biological_processGO:0003169 coronary vein morphogenesis ISS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007498 mesoderm development ISS
 biological_processGO:0007595 lactation ISS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030224 monocyte differentiation IDA
 biological_processGO:0030225 macrophage differentiation IDA
 biological_processGO:0030324 lung development ISS
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process IDA
 biological_processGO:0030855 epithelial cell differentiation ISS
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0031077 post-embryonic camera-type eye development ISS
 biological_processGO:0031334 positive regulation of protein complex assembly IDA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IDA
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0035148 tube formation IDA
 biological_processGO:0035767 endothelial cell chemotaxis IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:0036303 lymph vessel morphogenesis ISS
 biological_processGO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway IDA
 biological_processGO:0038190 VEGF-activated neuropilin signaling pathway ISS
 biological_processGO:0040007 growth ISS
 biological_processGO:0042462 eye photoreceptor cell development ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043129 surfactant homeostasis ISS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0048469 cell maturation ISS
 biological_processGO:0048593 camera-type eye morphogenesis ISS
 biological_processGO:0048739 cardiac muscle fiber development ISS
 biological_processGO:0048754 branching morphogenesis of an epithelial tube ISS
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance ISS
 biological_processGO:0048844 artery morphogenesis ISS
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050918 positive chemotaxis IDA
 biological_processGO:0050927 positive regulation of positive chemotaxis IDA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051272 positive regulation of cellular component movement IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IDA
 biological_processGO:0060319 primitive erythrocyte differentiation ISS
 biological_processGO:0060749 mammary gland alveolus development ISS
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 biological_processGO:0060948 cardiac vascular smooth muscle cell development ISS
 biological_processGO:0060982 coronary artery morphogenesis ISS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0071542 dopaminergic neuron differentiation ISS
 biological_processGO:0071679 commissural neuron axon guidance ISS
 biological_processGO:0090037 positive regulation of protein kinase C signaling IDA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0090259 regulation of retinal ganglion cell axon guidance ISS
 biological_processGO:0097475 motor neuron migration ISS
 biological_processGO:0097533 cellular stress response to acid chemical IDA
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IDA
 biological_processGO:1901727 positive regulation of histone deacetylase activity IDA
 biological_processGO:1902336 positive regulation of retinal ganglion cell axon guidance ISS
 biological_processGO:1903572 positive regulation of protein kinase D signaling IDA
 biological_processGO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IGI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0005125 cytokine activity ISS
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity ISS
 molecular_functionGO:0008201 heparin binding IMP
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding IPI
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0048018 receptor ligand activity IPI
 molecular_functionGO:0050840 extracellular matrix binding IC


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of gene expression by Hypoxia-inducible Factor
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
Interleukin-4 and Interleukin-13 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000089159 PXN / P49023 / paxillin  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000120899 PTK2B / Q14289 / protein tyrosine kinase 2 beta  / reaction / complex
 ENSG00000129946 SHC2 / P98077 / SHC adaptor protein 2  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction / complex
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / reaction / complex
 ENSG00000102755 FLT1 / P17948 / fms related tyrosine kinase 1  / reaction / complex
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / reaction / complex
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000167601 AXL / P30530 / AXL receptor tyrosine kinase  / reaction / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / reaction / complex
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000027869 Q9NP31 / SH2D2A / SH2 domain containing 2A  / reaction / complex
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction






 

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