ENSDARG00000034700


Danio rerio

Features
Gene ID: ENSDARG00000034700
  
Biological name :vegfab
  
Synonyms : vascular endothelial growth factor Ab / vegfab
  
Possible biological names infered from orthology : P15692 / Q00731 / vascular endothelial growth factor A / VEGFA
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 5568688
Gene end: 5597802
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000101780
Ensembl peptide - ENSDARP00000120079
Ensembl peptide - ENSDARP00000120175
swissprot - F1QDN7
swissprot - F1QTG5
swissprot - Q5RHW5
ZFIN ID - ZDB-GENE-030131-4605
Ensembl - ENSDARG00000034700
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VEGFAENSGALG00000010290Gallus gallus
 VEGFAENSG00000112715Homo sapiens
 VegfaENSMUSG00000023951Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*ENSDARG0000010354241
vegfba / vascular endothelial growth factor Ba / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*ENSDARG0000009099726
pgfb / placental growth factor b / PGF* / P49764* / P49763* / placental growth factor*ENSDARG0000007676725
CABZ01077555.1 / PGF* / P49763* / placental growth factor*ENSDARG0000011535918
vegfbb / vascular endothelial growth factor Bb / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*ENSDARG0000009248013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR027928  Vascular endothelial growth factor, heparin-binding domain
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0002040 sprouting angiogenesis IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding IBA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism lacks all parts of type basilar artery , abnormal
whole organism lacks all parts of type central artery , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
Show

 ZFA:0005035 subintestinal vein subintestinal vein malformed , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte position , abnormal
nucleate erythrocyte mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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