ENSDARG00000090997


Danio rerio

Features
Gene ID: ENSDARG00000090997
  
Biological name :vegfba
  
Synonyms : vascular endothelial growth factor Ba / vegfba
  
Possible biological names infered from orthology : P49765 / P49766 / vascular endothelial growth factor B / VEGFB
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 8504410
Gene end: 8573479
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000109240
NCBI entrez gene - 101885552     See in Manteia.
swissprot - E7EZR4
ZFIN ID - ZDB-GENE-120510-3
Ensembl - ENSDARG00000090997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VEGFBENSG00000173511Homo sapiens
 VegfbENSMUSG00000024962Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*ENSDARG0000010354226
vegfab / vascular endothelial growth factor Ab / VEGFA* / P15692* / Q00731* / vascular endothelial growth factor A*ENSDARG0000003470026
pgfb / placental growth factor b / PGF* / P49764* / P49763* / placental growth factor*ENSDARG0000007676720
vegfbb / vascular endothelial growth factor Bb / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*ENSDARG0000009248016
CABZ01077555.1 / PGF* / P49763* / placental growth factor*ENSDARG0000011535916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR027928  Vascular endothelial growth factor, heparin-binding domain
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 biological_processGO:0061300 cerebellum vasculature development IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
brain degenerate , abnormal
brain edematous , abnormal
brain hemorrhagic , abnormal
brain nucleate erythrocyte aggregated , abnormal
Show

 ZFA:0000029 hindbrain hindbrain vasculature development disrupted , abnormal
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 ZFA:0000099 brain vasculature brain vasculature morphology , abnormal
brain vasculature morphology , ameliorated
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 ZFA:0000128 midbrain midbrain vasculature development disrupted , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased length , abnormal
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 ZFA:0005010 mid cerebral vein mid cerebral vein absent , abnormal
mid cerebral vein decreased length , abnormal
mid cerebral vein morphology , ameliorated
Show

 ZFA:0005046 hyaloid vessel hyaloid vessel hypoplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000090997 vegfba / vascular endothelial growth factor Ba / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*  / complex
 ENSDARG00000092480 vegfbb / vascular endothelial growth factor Bb / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*  / complex
 ENSDARG00000019371 flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*  / complex / reaction






 

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