ENSMUSG00000024962


Mus musculus

Features
Gene ID: ENSMUSG00000024962
  
Biological name :Vegfb
  
Synonyms : P49766 / vascular endothelial growth factor B / Vegfb
  
Possible biological names infered from orthology : P49765
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6982473
Gene end: 6987651
  
Corresponding Affymetrix probe sets: 10465559 (MoGene1.0st)   1451803_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025914
Ensembl peptide - ENSMUSP00000120860
NCBI entrez gene - 22340     See in Manteia.
MGI - MGI:106199
RefSeq - NM_001185164
RefSeq - NM_011697
RefSeq Peptide - NP_001172093
RefSeq Peptide - NP_035827
swissprot - P49766
Ensembl - ENSMUSG00000024962
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vegfbaENSDARG00000090997Danio rerio
 vegfbbENSDARG00000092480Danio rerio
 VEGFBENSG00000173511Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vegfa / Q00731 / vascular endothelial growth factor A / P15692*ENSMUSG0000002395126
Pgf / P49764 / placental growth factor / P49763*ENSMUSG0000000479121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine
 IPR036841  Vascular endothelial growth factor, heparin-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0006493 protein O-linked glycosylation IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0035470 positive regulation of vascular wound healing ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:0060754 positive regulation of mast cell chemotaxis ISO
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042056 chemoattractant activity ISO
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding ISO
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lancl1em1Vdd/Lancl1em1Vdd,Lancl2em1Vdd/Lancl2em1Vdd,Lancl3em1Vdd/Lancl3em1Vdd
Genetic Background: FVB/N-Lancl1em1Vdd Lancl2em1Vdd Lancl3em1Vdd

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Lancl1em1Vdd/Lancl1em1Vdd,Lancl2em1Vdd/Lancl2em1Vdd,Lancl3em1Vdd/Lancl3em1Vdd
Genetic Background: FVB/N-Lancl1em1Vdd Lancl2em1Vdd Lancl3em1Vdd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003039 increased time of peak ischemic contracture "increased duration of time from normal necessary to achieve full irreversible contraction of the cardiac muscle in response to myocardial infarction" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003547 abnormal pulmonary pressure "altered tension of the blood within the pulmonary arteries" [J:54986, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003913 increased right ventricle weight "greater than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0020520 whitened brown adipose tissue morphology "brown adipose tissue displays a morphology more closely resembling white adipose tissue (eg. unilocular lipid droplets, decreased lipid droplet numbers)" [MGI:mperry, PMID:24703692]
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Allelic Composition: Lancl1em1Vdd/Lancl1em1Vdd,Lancl2em1Vdd/Lancl2em1Vdd,Lancl3em1Vdd/Lancl3em1Vdd
Genetic Background: FVB/N-Lancl1em1Vdd Lancl2em1Vdd Lancl3em1Vdd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024962 Vegfb / P49766 / vascular endothelial growth factor B / P49765*  / complex
 ENSMUSG00000029648 Flt1 / fms related tyrosine kinase 1 / P17948*  / reaction / complex






 

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