ENSMUSG00000004791


Mus musculus

Features
Gene ID: ENSMUSG00000004791
  
Biological name :Pgf
  
Synonyms : P49764 / Pgf / placental growth factor
  
Possible biological names infered from orthology : P49763
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D1
Gene start: 85166635
Gene end: 85177790
  
Corresponding Affymetrix probe sets: 10401607 (MoGene1.0st)   1418471_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004913
Ensembl peptide - ENSMUSP00000152165
NCBI entrez gene - 18654     See in Manteia.
MGI - MGI:105095
RefSeq - XM_011244016
RefSeq - NM_001271705
RefSeq - NM_008827
RefSeq - XM_006515585
RefSeq Peptide - NP_032853
RefSeq Peptide - NP_001258634
swissprot - P49764
swissprot - Q544A5
swissprot - A0A1Y7VIW3
Ensembl - ENSMUSG00000004791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01077555.1ENSDARG00000115359Danio rerio
 pgfbENSDARG00000076767Danio rerio
 PGFENSGALG00000026557Gallus gallus
 PGFENSG00000119630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vegfa / Q00731 / vascular endothelial growth factor A / P15692*ENSMUSG0000002395144
Vegfb / P49766 / vascular endothelial growth factor B / P49765*ENSMUSG0000002496228


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060688 regulation of morphogenesis of a branching structure IDA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0001619 abnormal vascular permeability "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pgftm1Pec/Pgftm1Pec
Genetic Background: involves: 129/Sv

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004791 Pgf / P49764 / placental growth factor / P49763*  / complex
 ENSMUSG00000029648 Flt1 / fms related tyrosine kinase 1 / P17948*  / complex / reaction






 

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