ENSG00000119630


Homo sapiens

Features
Gene ID: ENSG00000119630
  
Biological name :PGF
  
Synonyms : P49763 / PGF / placental growth factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.3
Gene start: 74941834
Gene end: 74955784
  
Corresponding Affymetrix probe sets: 209652_s_at (Human Genome U133 Plus 2.0 Array)   215179_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000238607
Ensembl peptide - ENSP00000385365
Ensembl peptide - ENSP00000451040
Ensembl peptide - ENSP00000451413
NCBI entrez gene - 5228     See in Manteia.
OMIM - 601121
RefSeq - NM_001207012
RefSeq - NM_001293643
RefSeq - NM_002632
RefSeq Peptide - NP_001193941
RefSeq Peptide - NP_001280572
RefSeq Peptide - NP_002623
swissprot - Q53XY6
swissprot - G3XA84
swissprot - P49763
Ensembl - ENSG00000119630
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01077555.1ENSDARG00000115359Danio rerio
 pgfbENSDARG00000076767Danio rerio
 PGFENSGALG00000026557Gallus gallus
 PgfENSMUSG00000004791Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VEGFA / P15692 / vascular endothelial growth factor AENSG0000011271540
VEGFB / P49765 / vascular endothelial growth factor BENSG0000017351128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060688 regulation of morphogenesis of a branching structure IEA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102755 FLT1 / P17948 / fms related tyrosine kinase 1  / complex / reaction
 ENSG00000119630 PGF / P49763 / placental growth factor  / complex






 

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