ENSG00000102755


Homo sapiens

Features
Gene ID: ENSG00000102755
  
Biological name :FLT1
  
Synonyms : FLT1 / fms related tyrosine kinase 1 / P17948
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.3
Gene start: 28300344
Gene end: 28495145
  
Corresponding Affymetrix probe sets: 204406_at (Human Genome U133 Plus 2.0 Array)   210287_s_at (Human Genome U133 Plus 2.0 Array)   222033_s_at (Human Genome U133 Plus 2.0 Array)   226497_s_at (Human Genome U133 Plus 2.0 Array)   226498_at (Human Genome U133 Plus 2.0 Array)   232809_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484832
Ensembl peptide - ENSP00000484385
Ensembl peptide - ENSP00000491097
Ensembl peptide - ENSP00000282397
Ensembl peptide - ENSP00000437631
Ensembl peptide - ENSP00000437841
Ensembl peptide - ENSP00000442630
Ensembl peptide - ENSP00000443311
Ensembl peptide - ENSP00000484039
NCBI entrez gene - 2321     See in Manteia.
OMIM - 165070
RefSeq - XM_017020485
RefSeq - NM_001159920
RefSeq - NM_001160030
RefSeq - NM_001160031
RefSeq - NM_002019
RefSeq - XM_011535014
RefSeq Peptide - NP_001153502
RefSeq Peptide - NP_001153392
RefSeq Peptide - NP_001153503
RefSeq Peptide - NP_002010
swissprot - L7RSL3
swissprot - H9N1E7
swissprot - A0A1W2PNW4
swissprot - P17948
swissprot - H9N1E8
Ensembl - ENSG00000102755
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flt1ENSDARG00000019371Danio rerio
 FLT1ENSGALG00000017091Gallus gallus
 Flt1ENSMUSG00000029648Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDR / P35968 / kinase insert domain receptorENSG0000012805244
FLT4 / P35916 / fms related tyrosine kinase 4ENSG0000003728039
P16234 / PDGFRA / platelet derived growth factor receptor alphaENSG0000013485324
P09619 / PDGFRB / platelet derived growth factor receptor betaENSG0000011372122
CSF1R / P07333 / colony stimulating factor 1 receptorENSG0000018257821
KIT / P10721 / KIT proto-oncogene receptor tyrosine kinaseENSG0000015740421
FLT3 / P36888 / fms related tyrosine kinase 3ENSG0000012202519
RET / P07949 / ret proto-oncogeneENSG0000016573118
FGFR2 / P21802 / fibroblast growth factor receptor 2ENSG0000006646818
FGFR1 / P11362 / fibroblast growth factor receptor 1ENSG0000007778217
FGFR3 / P22607 / fibroblast growth factor receptor 3ENSG0000006807817
FGFR4 / P22455 / fibroblast growth factor receptor 4ENSG0000016086717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009135  Vascular endothelial growth factor receptor 1 (VEGFR1)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002548 monocyte chemotaxis IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010863 positive regulation of phospholipase C activity IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:0036323 vascular endothelial growth factor receptor-1 signaling pathway IDA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0048514 blood vessel morphogenesis ISS
 biological_processGO:0048598 embryonic morphogenesis ISS
 biological_processGO:1905563 negative regulation of vascular endothelial cell proliferation IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IPI
 molecular_functionGO:0036326 VEGF-A-activated receptor activity IDA
 molecular_functionGO:0036327 VEGF-B-activated receptor activity IDA
 molecular_functionGO:0036332 placental growth factor-activated receptor activity IDA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000119630 PGF / P49763 / placental growth factor  / complex / reaction
 ENSG00000118257 NRP2 / O60462 / neuropilin 2  / reaction / complex
 ENSG00000102755 FLT1 / P17948 / fms related tyrosine kinase 1  / reaction / complex
 ENSG00000173511 VEGFB / P49765 / vascular endothelial growth factor B  / reaction / complex






 

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