ENSG00000118257


Homo sapiens

Features
Gene ID: ENSG00000118257
  
Biological name :NRP2
  
Synonyms : neuropilin 2 / NRP2 / O60462
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.3
Gene start: 205681990
Gene end: 205798133
  
Corresponding Affymetrix probe sets: 1555468_at (Human Genome U133 Plus 2.0 Array)   210841_s_at (Human Genome U133 Plus 2.0 Array)   210842_at (Human Genome U133 Plus 2.0 Array)   211844_s_at (Human Genome U133 Plus 2.0 Array)   214632_at (Human Genome U133 Plus 2.0 Array)   219367_s_at (Human Genome U133 Plus 2.0 Array)   222877_at (Human Genome U133 Plus 2.0 Array)   223510_at (Human Genome U133 Plus 2.0 Array)   225566_at (Human Genome U133 Plus 2.0 Array)   228699_at (Human Genome U133 Plus 2.0 Array)   229225_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353582
Ensembl peptide - ENSP00000350432
Ensembl peptide - ENSP00000387519
Ensembl peptide - ENSP00000407626
Ensembl peptide - ENSP00000404279
Ensembl peptide - ENSP00000272849
Ensembl peptide - ENSP00000349632
NCBI entrez gene - 8828     See in Manteia.
OMIM - 602070
RefSeq - XM_017005188
RefSeq - NM_003872
RefSeq - NM_018534
RefSeq - NM_201264
RefSeq - NM_201266
RefSeq - NM_201267
RefSeq - NM_201279
RefSeq - XM_005246933
RefSeq - XM_005246934
RefSeq - XM_017005185
RefSeq - XM_017005186
RefSeq - XM_017005187
RefSeq Peptide - NP_957718
RefSeq Peptide - NP_957719
RefSeq Peptide - NP_958436
RefSeq Peptide - NP_003863
RefSeq Peptide - NP_061004
RefSeq Peptide - NP_957716
swissprot - Q7LBX6
swissprot - C9JH98
swissprot - A0A024R412
swissprot - X5D2Q8
swissprot - A0A024R3W6
swissprot - O60462
Ensembl - ENSG00000118257
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRP2ENSGALG00000008621Gallus gallus
 Nrp2ENSMUSG00000025969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRP1 / O14786 / neuropilin 1ENSG0000009925044
F8 / P00451 / coagulation factor VIIIENSG0000018501018
F5 / P12259 / coagulation factor VENSG0000019873417
EDIL3 / O43854 / EGF like repeats and discoidin domains 3ENSG0000016417614
DCBLD2 / Q96PD2 / discoidin, CUB and LCCL domain containing 2ENSG0000005701913
MFGE8 / Q08431 / milk fat globule-EGF factor 8 proteinENSG0000014054513
DCBLD1 / Q8N8Z6 / discoidin, CUB and LCCL domain containing 1ENSG0000016446510
HEPHL1 / Q6MZM0 / hephaestin like 1ENSG000001813338
HEPH / Q9BQS7 / hephaestinENSG000000894728
CP / P00450 / ceruloplasminENSG000000474578
RS1 / O15537 / retinoschisin 1ENSG000001021046


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR000998  MAM domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014648  Neuropilin
 IPR022579  Neuropilin, C-terminal
 IPR027143  Neuropilin-2
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation TAS
 biological_processGO:0003148 outflow tract septum morphogenesis ISS
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration TAS
 biological_processGO:0021675 nerve development ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048846 axon extension involved in axon guidance ISS
 biological_processGO:0061549 sympathetic ganglion development ISS
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0097490 sympathetic neuron projection extension ISS
 biological_processGO:0097491 sympathetic neuron projection guidance ISS
 biological_processGO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance ISS
 cellular_componentGO:0002116 semaphorin receptor complex NAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0019838 growth factor binding TAS
 molecular_functionGO:0019955 cytokine binding NAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
NrCAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102755 FLT1 / P17948 / fms related tyrosine kinase 1  / reaction / complex
 ENSG00000118257 NRP2 / O60462 / neuropilin 2  / complex / reaction
 ENSG00000091129 NRCAM / Q92823 / neuronal cell adhesion molecule  / reaction / complex






 

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